Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Computational biochemistry

Models of transition

Is it possible to determine the role of an enzyme from its structure? The latest findings suggest that it is, and prove the point by predicting the substrate for an enzyme of unknown function.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Chemical transformations of enzyme superfamilies.

References

  1. http://www.genomesonline.org

  2. Hermann, J. C. et al. Nature 448, 775–779 (2007).

    Article  ADS  CAS  Google Scholar 

  3. Gerlt, J. A. & Babbit, P. C. Annu. Rev. Biochem. 70, 209–246 (2001).

    Article  CAS  Google Scholar 

  4. Kanehisa, M. & Goto, S. Nucleic Acids Res. 28, 27–30 (2000).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Stubbe, J. Models of transition. Nature 448, 762–763 (2007). https://doi.org/10.1038/448762a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/448762a

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing