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Nature 448, 613-616 (15 July 2007) | doi:10.1038/nature06009;
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Postdoctoral Associate in Enzyme Biochemistry
- Cornell University
- Ithaca, NY
Tenure-track Faculty Positions
- University of Michigan
- Ann Arbor, Michigan, USA
Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase
Cysteinyl leukotrienes are key mediators in inflammation and have an important role in acute and chronic inflammatory diseases of the cardiovascular and respiratory systems, in particular bronchial asthma. In the biosynthesis of cysteinyl leukotrienes, conversion of arachidonic acid forms the unstable epoxide leukotriene A4 (LTA4).
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