Electrical stimulation improves brain function after severe injury.
doi:10.1038/7153xiiia
Table of contents
Volume 448 Number 7153 pp511-622
(this content only available online) indicates content that is available online only
Making the paper: Nicholas Schiff pxiii
Abstractions pxiii
doi:10.1038/7153xiiib
From the blogosphere pxiii
doi:10.1038/7153xiiic
Top of page
Editorials
Free at last p511
The liberation of six foreign health workers, held without cause in Libya, is to be welcomed. Now Libya should face facts — and clear their names.
doi:10.1038/448511a
Board games p511
The way research on human subjects is overseen in the United States requires reform.
doi:10.1038/448511b
A sporting chance p512
Bans on drug enhancement in sport may go the way of earlier prohibitions on women and remuneration.
doi:10.1038/448512a
Top of page
Research Highlights
Research highlights p514
doi:10.1038/448514a
Correction p515
doi:10.1038/448515a
Top of page
Special report
News
The mouse map gets a lot more signposts p516
Q&A: Jürgen Graeser p517
The first Westerner invited to spend time on a Russian drifting station contemplates his eight-month voyage to the North Pole.
doi:10.1038/448517a
Special report
China's green accounting system on shaky ground p518
Beijing is attempting to introduce a 'green GDP' accounting scheme as a way of ranking local governments' success in achieving economic growth that does not cost the environment. But the scheme is faltering at the pilot stage due to political infighting, says Jane Qiu.
Jane Qiu
doi:10.1038/448518a
Sidelines p520
doi:10.1038/448520a
Russia at forefront of Arctic land-grab p520
Countries battle over ownership of lucrative seabed.
Daniel Cressey
doi:10.1038/448520b
New life for nuclear warheads p520
US starts work on its first mixed-oxide plant.
Geoff Brumfiel
doi:10.1038/448520c
Implant boosts activity in injured brain p522
Deep-brain stimulation offers hope for minimally conscious patients.
Michael Hopkin
doi:10.1038/448522a
Flatworms' starring role in stem-cell research p522
Biologists hope insight into cell differentiation and communication will transfer to humans.
Heidi Ledford
doi:10.1038/448522b
Top of page
Column
Party of OneMaking room for dissent p524
Washington has reached an easy consensus on the need to train more scientists and engineers but, argues David Goldston, the United States needs to consider a broader approach to combat global competition.
David Goldston
doi:10.1038/448524a
Top of page
Business
Swiss on a roll p525
Smart investors who know the drugs business well are helping to make Zurich's stock market a popular place for biotechnology firms to raise money. Andrea Chipman reports.
doi:10.1038/448525a
Top of page
News Features
Future crops: The other greenhouse effect p526
Rising carbon dioxide levels should increase crop yields. But what if their effect on the nutritional value of our food is less benign, asks Ned Stafford.
Ned Stafford
doi:10.1038/448526a
Human-subjects research: Trial and error p530
The ethics committees that oversee research done in humans have been attacked from all sides. Heidi Ledford recounts the struggle to come up with alternatives.
Heidi Ledford
doi:10.1038/448530a
Top of page
Correspondence
Profit or perish even worse than publish or perish p533
Interdisciplinary research could pull cash into science p533
The 'hundred surnames' of China run into thousands p533
University speaks up in dispute over cancer centre p533
Climate information helps homeowners make choices p533
Top of page
Books and Arts
Social climbers p535
Does a baboon's success in social situations depend solely on learning the rules of the game?
doi:10.1038/448535a
The atomic peacemaker p536
doi:10.1038/448536a
Nervous systems made simple p537
doi:10.1038/448537a
Science in culture: Consulting nature's pattern-book p538
Peter Randall-Page's massive granite sculpture for the Eden Project emulates natural form.
Martin Kemp
doi:10.1038/448538a
Top of page
News and Views
神経学: 目覚め
Neurology: An awakening p539
Neuroscientists and engineers are developing ways to help patients overcome paralysis and stroke. But what about mental function itself? Can medical intervention restore consciousness?
Michael N. Shadlen & Roozbeh Kiani
doi:10.1038/448539a
日本語要約 | Full Text | PDF (233K)
気候変動: エーロゾルでヒートアップ
Climate change: Aerosols heat up p541
Solid particles suspended in the atmosphere have long played second fiddle to greenhouse gases as agents of climate change. A study of atmospheric heating over the Indian Ocean could provoke a rethink.
Peter Pilewskie
doi:10.1038/448541a
日本語要約 | Full Text | PDF (210K)
微生物学: 内部情報
Microbiology: The inside story p542
The human intestine is home to trillions of bacteria. Investigation of the colonization of the infant gut by these microorganisms is a prelude to understanding how they may act in both health and disease.
Laurie E. Comstock
doi:10.1038/448542a
日本語要約 | Full Text | PDF (241K)
応用物理学: ビットの競争
Applied physics: Champing at the bit p544
When two 'bits' of magnetic information race around a nanoscale wire, two factors determine whether or not they survive the course: the condition of the track, and how fast they respond to the starting signal.
Russell P. Cowburn
doi:10.1038/448544a
日本語要約 | Full Text | PDF (601K)
癌: 固形腫瘍中の壊れた遺伝子
Cancer: Broken genes in solid tumours p545
Mutations that cause portions of two genes to fuse together and form a hybrid gene are frequent in blood-related cancers. New findings implicate one such fusion gene in the most common type of lung cancer.
Matthew Meyerson
doi:10.1038/448545a
日本語要約 | Full Text | PDF (513K)
50 & 100 Years Ago p546
doi:10.1038/448546a
磁性: 管理された混乱状態
Magnetism: Managed mess p546
The presence of non-magnetic atoms can create a random internal field in magnetic crystals. Tuning that field from outside allows the intrinsic magnetic properties of the material to be precisely controlled.
Zachary Fisk
doi:10.1038/448546b
日本語要約 | Full Text | PDF (205K)
癌: 恐るべき三角関係
Cancer: An infernal triangle p547
Signals induced by sex hormones and inflammation have been viewed as different aspects of tumour development. But a three-way interaction between these two classes of signal and carcinogenesis has emerged.
Alberto Mantovani
doi:10.1038/448547a
日本語要約 | Full Text | PDF (292K)
ゲノム生物学: エピゲノム時代の到来
Genomic biology: The epigenomic era opens p548
Readout of information from the genome depends on intricate regulation of how DNA is packaged by proteins. The great endeavour to reveal how this packaging operates pan-genomically is now under way.
Stephen B. Baylin & Kornel E. Schuebel
doi:10.1038/448548a
日本語要約 | Full Text | PDF (725K)
Top of page
News and Views Q&A
生物多様性: 気候変動と生態学
Biodiversity: Climate change and the ecologist p550
The evidence for rapid climate change now seems overwhelming. Global temperatures are predicted to rise by up to 4 °C by 2100, with associated alterations in precipitation patterns. Assessing the consequences for biodiversity, and how they might be mitigated, is a Grand Challenge in ecology.
Wilfried Thuiller
doi:10.1038/448550a
日本語要約 | Full Text | PDF (517K)
Top of page
Articles
多能性細胞と系列拘束された細胞におけるクロマチンの状態を示すゲノム全域にわたる地図
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells p553
Tarjei S. Mikkelsen, Manching Ku, David B. Jaffe, Biju Issac, Erez Lieberman, Georgia Giannoukos, Pablo Alvarez, William Brockman, Tae-Kyung Kim, Richard P. Koche, William Lee, Eric Mendenhall, Aisling O'Donovan, Aviva Presser, Carsten Russ, Xiaohui Xie, Alexander Meissner, Marius Wernig, Rudolf Jaenisch, Chad Nusbaum, Eric S. Lander & Bradley E. Bernstein
doi:10.1038/nature06008
非小細胞肺癌におけるEML4-ALK融合型トランスフォーミング遺伝子の同定
Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer p561
Manabu Soda, Young Lim Choi, Munehiro Enomoto, Shuji Takada, Yoshihiro Yamashita, Shunpei Ishikawa, Shin-ichiro Fujiwara, Hideki Watanabe, Kentaro Kurashina, Hisashi Hatanaka, Masashi Bando, Shoji Ohno, Yuichi Ishikawa, Hiroyuki Aburatani, Toshiro Niki, Yasunori Sohara, Yukihiko Sugiyama & Hiroyuki Mano
doi:10.1038/nature05945
日本語要約 | Full Text | PDF (1,261K) | Supplementary information
Top of page
Letters
連続的に調整可能なランダム場における強磁性体
A ferromagnet in a continuously tunable random field p567
D. M. Silevitch, D. Bitko, J. Brooke, S. Ghosh, G. Aeppli & T. F. Rosenbaum
doi:10.1038/nature06050
日本語要約 | Full Text | PDF (327K)
室温における単一グラフェン層内の電子スピン輸送とスピン歳差運動
Electronic spin transport and spin precession in single graphene layers at room temperature p571
Nikolaos Tombros, Csaba Jozsa, Mihaita Popinciuc, Harry T. Jonkman & Bart J. van Wees
doi:10.1038/nature06037
日本語要約 | Full Text | PDF (479K)
褐色雲による太陽光吸収が拡大するアジアの温暖化傾向
Warming trends in Asia amplified by brown cloud solar absorption p575
Veerabhadran Ramanathan, Muvva V. Ramana, Gregory Roberts, Dohyeong Kim, Craig Corrigan, Chul Chung & David Winker
doi:10.1038/nature06019
大きな一時的剪断応力により起きた非火山性微動
Non-volcanic tremor driven by large transient shear stresses p579
Justin L. Rubinstein, John E. Vidale, Joan Gomberg, Paul Bodin, Kenneth C. Creager & Stephen D. Malone
doi:10.1038/nature06017
日本語要約 | Full Text | PDF (1,058K) | Supplementary information
最古の硬骨魚類の顎と歯
Jaws and teeth of the earliest bony fishes p583
Hector Botella, Henning Blom, Markus Dorka, Per Erik Ahlberg & Philippe Janvier
doi:10.1038/nature05989
単一遺伝子に起きた複数のシス調節変異による形態的進化
Morphological evolution through multiple cis-regulatory mutations at a single gene p587
Alistair P. McGregor, Virginie Orgogozo, Isabelle Delon, Jennifer Zanet, Dayalan G. Srinivasan, François Payre & David L. Stern
doi:10.1038/nature05988
全ゲノム関連解析によりKIAA0350を1型糖尿病遺伝子として同定
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene p591
Hakon Hakonarson, Struan F. A. Grant, Jonathan P. Bradfield, Luc Marchand, Cecilia E. Kim, Joseph T. Glessner, Rosemarie Grabs, Tracy Casalunovo, Shayne P. Taback, Edward C. Frackelton, Margaret L. Lawson, Luke J. Robinson, Robert Skraban, Yang Lu, Rosetta M. Chiavacci, Charles A. Stanley, Susan E. Kirsch, Eric F. Rappaport, Jordan S. Orange, Dimitri S. Monos, Marcella Devoto, Hui-Qi Qu & Constantin Polychronakos
doi:10.1038/nature06010
異なる種類の染色体再配列が前立腺癌における発癌性ETS遺伝子の融合を引き起こす
Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer p595
Scott A. Tomlins, Bharathi Laxman, Saravana M. Dhanasekaran, Beth E. Helgeson, Xuhong Cao, David S. Morris, Anjana Menon, Xiaojun Jing, Qi Cao, Bo Han, Jindan Yu, Lei Wang, James E. Montie, Mark A. Rubin, Kenneth J. Pienta, Diane Roulston, Rajal B. Shah, Sooryanarayana Varambally, Rohit Mehra & Arul M. Chinnaiyan
doi:10.1038/nature06024
重篤な脳外傷後の視床刺激による行動能力改善
Behavioural improvements with thalamic stimulation after severe traumatic brain injury p600
N. D. Schiff, J. T. Giacino, K. Kalmar, J. D. Victor, K. Baker, M. Gerber, B. Fritz, B. Eisenberg, J. O'Connor, E. J. Kobylarz, S. Farris, A. Machado, C. McCagg, F. Plum, J. J. Fins & A. R. Rezai
doi:10.1038/nature06041
共通のエフェクター処理が刺激に対する細胞特異応答を仲介する
Common effector processing mediates cell-specific responses to stimuli p604
Kathryn Miller-Jensen, Kevin A. Janes, Joan S. Brugge & Douglas A. Lauffenburger
doi:10.1038/nature06001
システイニルロイコトリエン生合成にかかわるヒト膜タンパク質の結晶構造
Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis p609
Hideo Ago, Yoshihide Kanaoka, Daisuke Irikura, Bing K. Lam, Tatsuro Shimamura, K. Frank Austen & Masashi Miyano
doi:10.1038/nature05936
ヒトロイコトリエンC4合成酵素による炎症メディエーター合成の構造基盤
Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase p613
Daniel Martinez Molina, Anders Wetterholm, Andreas Kohl, Andrew A. McCarthy, Damian Niegowski, Eva Ohlson, Tove Hammarberg, Said Eshaghi, Jesper Z. Haeggström & Pär Nordlund
doi:10.1038/nature06009
Top of page
Special Report
Highlights
Naturejobs
ProspectProspects p617
Climate science buzz doesn't necessarily translate into climate science jobs.
Gene Russo
doi:10.1038/nj7153-617a
Special Report
Climate of opportunity p618
Awareness about climate change is at an all-time high. Will this surge of attention translate into more jobs for climate scientists? Amanda Haag reports.
Amanda Haag
doi:10.1038/nj7153-618a
Highlights
Opportunities: The National Institutes of Health
doi:10.1038/nj0166
