FIGURE 3. Cell-type-specific chromatin marks at promoters.
From the following article:
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
Tarjei S. Mikkelsen, Manching Ku, David B. Jaffe, Biju Issac, Erez Lieberman, Georgia Giannoukos, Pablo Alvarez, William Brockman, Tae-Kyung Kim, Richard P. Koche, William Lee, Eric Mendenhall, Aisling O'Donovan, Aviva Presser, Carsten Russ, Xiaohui Xie, Alexander Meissner, Marius Wernig, Rudolf Jaenisch, Chad Nusbaum, Eric S. Lander & Bradley E. Bernstein
Nature 448, 553-560(2 August 2007)
doi:10.1038/nature06008

a, Multiple 'housekeeping genes', such as DNA polymerase
(Polm), are associated with HCPs marked by H3K4me3 in all cell types. b, The neural transcription factor gene Olig1 (HCP) is bivalent in ES cells, but resolves to H3K4me3 in NPCs and H3K27me3 in MEFs. c, The neurogenesis transcription factor gene Neurog1 (HCP) remains bivalent upon differentiation to NPCs, but resolves to H3K27me3 in MEFs. d, The adipogenesis transcription factor gene Pparg (HCP) remains bivalent in MEFs, but loses both marks in NPCs. e, The neural progenitor marker gene Fabp7 (LCP) is marked by H3K4me3 in NPCs only. f, The brain and lung expressed transcription factor gene Foxp2 is associated with an HCP that is bivalent in ES cells, but resolves to H3K4me3 in NPCs and remains bivalent in MEFs. g, Foxp2 also has an LCP marked by H3K4me3 in MEFs only. h, Multiple, distinct bivalent chromatin marks at the variable region promoters of Pcdhg. A promoter proximal to the constant region exons (asterisk) is marked by H3K4me3 only.
