Editor's Summary

2 August 2007

Novel diabetes gene

The discovery of a gene newly implicated in the pathogenesis of type 1 diabetes may boost the development of predictive tests. A genome-wide association study on DNA from more than 500 patients with type 1 diabetes confirms associations with known type-1-diabetes-related genes and a new link to the KIAA0350 gene. This encodes a sugar-binding C-type lectin, one of a group of proteins whose functions include carbohydrate recognition and cell adhesion.

Letter: A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene

Hakon Hakonarson, Struan F. A. Grant, Jonathan P. Bradfield, Luc Marchand, Cecilia E. Kim, Joseph T. Glessner, Rosemarie Grabs, Tracy Casalunovo, Shayne P. Taback, Edward C. Frackelton, Margaret L. Lawson, Luke J. Robinson, Robert Skraban, Yang Lu, Rosetta M. Chiavacci, Charles A. Stanley, Susan E. Kirsch, Eric F. Rappaport, Jordan S. Orange, Dimitri S. Monos, Marcella Devoto, Hui-Qi Qu & Constantin Polychronakos

doi:10.1038/nature06010

First paragraph | Full Text | PDF (310K) | Supplementary information