Supplementary information

From the following article:

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

John D. Carpten, Andrew L. Faber, Candice Horn, Gregory P. Donoho, Stephen L. Briggs, Christiane M. Robbins, Galen Hostetter, Sophie Boguslawski, Tracy Y. Moses, Stephanie Savage, Mark Uhlik, Aimin Lin, Jian Du, Yue-Wei Qian, Douglas J. Zeckner, Greg Tucker-Kellogg, Jeffrey Touchman, Ketan Patel, Spyro Mousses, Michael Bittner, Richard Schevitz, Mei-Huei T. Lai, Kerry L. Blanchard & James E. Thomas

Nature 448, 439-444(26 July 2007)

doi:10.1038/nature05933

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Supplementary Information

This file contains Supplementary Figures 1-6 with Legends, Supplementary Tables 1 -2, Legends for Supplementary Movies 1-5.

Supplementary Video 1

This file contains Supplementary Video1 which shows the movement of GFP-PHwt in NIH3T3 cells over a period of several minutes after treatment with PDGF.

Supplementary Video 2

This file contains Supplementary Video 2 which shows the movement of GFP-PHE17K in NIH3T3 cells treated with PDGF over a period of several minutes.

Supplementary Video 3

This file contains Supplementary Video 3 which shows the movement of GFP-PHR25C in NIH3T3 cells over a period of several minutes after treatment with PDGF.

Supplementary Video 4

This file contains Supplementary Video 4 which shows the movement of GFP-PHwt in NIH3T3 cells over period of several minutes after treatment with LY294002 followed by treatment with PDGF.

Supplementary Video 5

This file contains Supplementary Video 5 which shows the movement of GFP-PHE17K in NIH3T3 cells over period of several minutes after treatment with LY294002 followed by treatment with PDGF. This legend was corrected on 18 July 2007.

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