How an eye lens protein protects the brain from disease.
doi:10.1038/7152xia
Table of contents
Volume 448 Number 7152 pp387-510
(this content only available online) indicates content that is available online only
Making the paper: Lawrence Steinman pxi
Abstractions pxi
doi:10.1038/7152xib
From the blogosphere pxi
doi:10.1038/7152xic
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Editorials
Nuclear test p387
Japan's response to an earthquake highlights both the promise and the pitfalls of nuclear power at a critical time for its future.
doi:10.1038/448387a
Storm brewing p387
It's the season of discord at US National Oceanic and Atmospheric Administration.
doi:10.1038/448387b
California dreaming p388
Universities should draw the line at certain types of support from the drug industry.
doi:10.1038/448388a
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News
Quake shuts world's largest nuclear plant p392
No one died as a result of Japan's latest nuclear incident and environmental damage seem have been mostly avoided. But is this testimony to successful plant design or a warning of impending disaster?
David Cyranoski
doi:10.1038/448392a
Darfur lake is a 'mirage' p394
Geologists dismiss claims for ancient water source.
Declan Butler
doi:10.1038/448394a
California campuses resist industry restrictions p394
Sidelines p396
doi:10.1038/448396a
Carbon sinks threatened by increasing ozone p396
Pollutant poisons plants and hampers photosynthesis.
Michael Hopkin
doi:10.1038/448396b
Diamonds 'melted' inside an onion p396
Memory seen in the making p397
Libyan ordeal ends: medics freed p398
Plane takes medical workers to a pardon in Bulgaria.
Declan Butler
doi:10.1038/448398a
Stem-cell researcher's move attracts funding p398
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Business
The pain game p400
The safety problems that brought down Vioxx have tainted a whole class of drugs. Meredith Wadman examines their chances of a comeback.
doi:10.1038/448400a
In brief p401
doi:10.1038/448401a
Market watch p401
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News Features
Conservation: Mark of respect p402
A project that gives Congolese pygmies new ways to tell logging companies about the trees that are important to them, and their own radio station to discuss community issues, is really putting their interests on the map, says Michael Hopkin.
Michael Hopkin
doi:10.1038/448402a
Science in comedy: Mmm... pi p404
Part of The Simpsons' greatness is a willingness to find the humour in absolutely everything — including science. Executive producer Al Jean, the show's head writer and a Harvard mathematics graduate, talks to Nature about how to get a laugh out of Euler's formula.
Michael Hopkin
doi:10.1038/448404a
Research policy: The map man p406
Alan Krensky has been put in charge of a controversial new office responsible for charting the progress of the NIH Roadmap for Medical Research. Meredith Wadman catches up with him in his first few days on the job.
Meredith Wadman
doi:10.1038/448406a
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Correspondence
Nobel laureates know what they're talking about p408
Nobel: politicians need the insights scientists can give p408
How a naturalist found safe colours for soldiers p408
Post-publication review could aid skills and quality p408
Correction p408
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Commentary
Driving a wedge into the Amazon p409
Things are heating up in the Amazon as the burning season begins. In Brazil, a 30-year-old study of forest fragments is itself threatened by farming, logging and hunting, say William Laurance and Regina Luizão.
William F. Laurance & Regina C. C. Luizão
doi:10.1038/448409a
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Books and Arts
A man of peace p411
One scientist's journey from the Manhattan Project to the Nobel Peace Prize.
doi:10.1038/448411a
Too much information p412
doi:10.1038/448412a
Introducing the extremophiles p413
doi:10.1038/448413a
Science in culture: Mind tricks p414
Cognitive scientists take a lesson from magicians.
Susana Martinez-Conde & Stephen L. Macknik
doi:10.1038/448414a
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News and Views
生化学: 抗生物質合成への未知なる道
Biochemistry: Uncharted route for antibiotics p415
In their battle for survival, soil microorganisms produce a vast arsenal of toxic molecules. One such toxin contains a unique sequence of atoms, and its biosynthesis includes some unexpected steps.
John P. Quinn
doi:10.1038/448415a
日本語要約 | Full Text | PDF (324K)
免疫: 自給自足するヘルパー細胞
Immunology: Narcissistic helpers p416
T helper-17 cells, which are involved in immune responses, arise from a pool of precursor cells. It emerges that their differentiation is partly mediated by the IL-21 protein, which originates from the helper cells themselves.
Matthew T. Palmer & Casey T. Weaver
doi:10.1038/448416a
日本語要約 | Full Text | PDF (345K)
50 & 100 Years Ago p417
doi:10.1038/448417a
宇宙生物学: 水の色と光合成
Astrobiology: Photosynthesis in watercolours p418
The spectrum of stellar radiation available to an organism is altered by the atmosphere and water on the planet it inhabits. Study of this relationship can outline the limits to photosynthesis.
John Raven
doi:10.1038/448418a
数学: ちょっとした組み立てが必要
Mathematics: Some assembly needed p419
Origami, the ancient Japanese art of paper folding, is mathematically deeper than it looks. Delving into its complexities allows the construction of elaborate and useful structures from simple, flat templates.
Ian Stewart
doi:10.1038/448419a
日本語要約 | Full Text | PDF (170K)
発生生物学: 10パーセントの解決
Developmental biology: A ten per cent solution p420
In early embryos, a concentration gradient of the Bicoid protein affects pattern formation. Studies of living embryos reveal a surprising level of accuracy in the Bicoid gradient. But is it accurate enough?
John Reinitz
doi:10.1038/448420a
日本語要約 | Full Text | PDF (219K)
炎症性疾患: 守護神を襲撃
Inflammatory disease: Assault on the guardian p421
In multiple sclerosis, the immune system attacks 'self' tissues. Ten years after the discovery of one target of this autoimmunity, work with mice identifies it as a guardian protein produced in response to inflammation.
Richard M. Ransohoff
doi:10.1038/448421a
日本語要約 | Full Text | PDF (170K)
量子計算: 対称性で強化する
Quantum computing: Powered by symmetry p422
Forces determine how particles move and behave. But so can symmetry, and exchange symmetry can be used to control the interactions of ultracold atoms. This could be a big step towards practical quantum computation.
Johannes Hecker Denschlag
doi:10.1038/448422a
日本語要約 | Full Text | PDF (167K)
免疫: 内部の敵を感知する
Immunology: Sensing the enemy within p423
Damaged or foreign DNA stimulates immune responses by inducing the production of interferon proteins. New evidence indicates that this response is mediated by a cytosolic DNA sensor known as DAI.
Hongbo Chi & Richard A. Flavell
doi:10.1038/448423a
日本語要約 | Full Text | PDF (596K)
追悼: Horst Tobias Witt氏（1922-2007）
Obituary: Horst Tobias Witt (1922–2007) p425
Seminal research on photosynthesis.
Wolfgang Junge & A. William Rutherford
doi:10.1038/448425a
日本語要約 | Full Text | PDF (148K)
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Articles
小胞体からの脱出用ハッチ形成を脂質の関与によって説明するモデル
A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum p435
癌におけるAKT1のプレクストリン相同ドメインでの腫瘍化変異
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer p439
John D. Carpten, Andrew L. Faber, Candice Horn, Gregory P. Donoho, Stephen L. Briggs, Christiane M. Robbins, Galen Hostetter, Sophie Boguslawski, Tracy Y. Moses, Stephanie Savage, Mark Uhlik, Aimin Lin, Jian Du, Yue-Wei Qian, Douglas J. Zeckner, Greg Tucker-Kellogg, Jeffrey Touchman, Ketan Patel, Spyro Mousses, Michael Bittner, Richard Schevitz, Mei-Huei T. Lai, Kerry L. Blanchard & James E. Thomas
doi:10.1038/nature05933
日本語要約 | Full Text | PDF (1,310K) | Supplementary information
c-MycによるDNA複製の非転写型調節
Non-transcriptional control of DNA replication by c-Myc p445
David Dominguez-Sola, Carol Y. Ying, Carla Grandori, Luca Ruggiero, Brenden Chen, Muyang Li, Denise A. Galloway, Wei Gu, Jean Gautier & Riccardo Dalla-Favera
doi:10.1038/nature05953
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Protective and therapeutic role for
Letters
光格子中で起こる中性原子対間の制御交換相互作用
Controlled exchange interaction between pairs of neutral atoms in an optical lattice p452
Marco Anderlini, Patricia J. Lee, Benjamin L. Brown, Jennifer Sebby-Strabley, William D. Phillips & J. V. Porto
doi:10.1038/nature06011
日本語要約 | Full Text | PDF (555K)
酸化グラフェンペーパーの作製と評価
Preparation and characterization of graphene oxide paper p457
Dmitriy A. Dikin, Sasha Stankovich, Eric J. Zimney, Richard D. Piner, Geoffrey H. B. Dommett, Guennadi Evmenenko, SonBinh T. Nguyen & Rodney S. Ruoff
doi:10.1038/nature06016
日本語要約 | Full Text | PDF (1,969K) | Supplementary information
人間活動が20世紀の降水量の変化傾向に及ぼした影響の検出
Detection of human influence on twentieth-century precipitation trends p461
Xuebin Zhang, Francis W. Zwiers, Gabriele C. Hegerl, F. Hugo Lambert, Nathan P. Gillett, Susan Solomon, Peter A. Stott & Toru Nozawa
doi:10.1038/nature06025
カリフォルニア湾におけるリフティング様式の変化
Variation in styles of rifting in the Gulf of California p466
Daniel Lizarralde, Gary J. Axen, Hillary E. Brown, John M. Fletcher, Antonio González-Fernández, Alistair J. Harding, W. Steven Holbrook, Graham M. Kent, Pedro Paramo, Fiona Sutherland & Paul J. Umhoefer
doi:10.1038/nature06035
ORMDL3発現を制御する遺伝子の変異は小児喘息のリスクの一因となる
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma p470
Miriam F. Moffatt, Michael Kabesch, Liming Liang, Anna L. Dixon, David Strachan, Simon Heath, Martin Depner, Andrea von Berg, Albrecht Bufe, Ernst Rietschel, Andrea Heinzmann, Burkard Simma, Thomas Frischer, Saffron A. G. Willis-Owen, Kenny C. C. Wong, Thomas Illig, Christian Vogelberg, Stephan K. Weiland, Erika von Mutius, Gonçalo R. Abecasis, Martin Farrall, Ivo G. Gut, G. Mark Lathrop & William O. C. Cookson
doi:10.1038/nature06014
自己免疫性の脱髄に対するαB-クリスタリンの保護作用と治療効果
Protective and therapeutic role for 
B-crystallin in autoimmune demyelination p474
Shalina S. Ousman, Beren H. Tomooka, Johannes M. van Noort, Eric F. Wawrousek, Kevin O'Conner, David A. Hafler, Raymond A. Sobel, William H. Robinson & Lawrence Steinman
doi:10.1038/nature05935
日本語要約 | Full Text | PDF (1,046K) | Supplementary information
炎症性T細胞の生成にはIL-21による自己分泌的制御が不可欠である
Essential autocrine regulation by IL-21 in the generation of inflammatory T cells p480
Roza Nurieva, Xuexian O. Yang, Gustavo Martinez, Yongliang Zhang, Athanasia D. Panopoulos, Li Ma, Kimberly Schluns, Qiang Tian, Stephanie S. Watowich, Anton M. Jetten & Chen Dong
doi:10.1038/nature05969
IL-21は炎症促進性TH17細胞を誘導する代替経路を開始する
IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells p484
Thomas Korn, Estelle Bettelli, Wenda Gao, Amit Awasthi, Anneli Jäger, Terry B. Strom, Mohamed Oukka & Vijay K. Kuchroo
doi:10.1038/nature05970
タンパク質分泌と再循環におけるごく近縁のARF-GEFの機能的多様化
Functional diversification of closely related ARF-GEFs in protein secretion and recycling p488
Sandra Richter, Niko Geldner, Jarmo Schrader, Hanno Wolters, York-Dieter Stierhof, Gabino Rios, Csaba Koncz, David G. Robinson & Gerd Jürgens
doi:10.1038/nature05967
日本語要約 | Full Text | PDF (2,070K) | Supplementary information
植物の極性細胞のゴルジ体と選択的エンドサイトーシスで働くARF-GEF
An ARF-GEF acting at the Golgi and in selective endocytosis in polarized plant cells p493
Ooi-kock Teh & Ian Moore
doi:10.1038/nature06023
日本語要約 | Full Text | PDF (1,426K) | Supplementary information
フラジェリンの誘導で生じる受容体FLS2とBAK1の複合体が植物の防御反応を開始させる
A flagellin-induced complex of the receptor FLS2 and BAK1 initiates plant defence p497
Delphine Chinchilla, Cyril Zipfel, Silke Robatzek, Birgit Kemmerling, Thorsten Nürnberger, Jonathan D. G. Jones, Georg Felix & Thomas Boller
doi:10.1038/nature05999
DAI（DLM-1/ZBP1）は細胞質内DNAセンサーであり、自然免疫応答の活性化を誘導する
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response p501
Akinori Takaoka, ZhiChao Wang, Myoung Kwon Choi, Hideyuki Yanai, Hideo Negishi, Tatsuma Ban, Yan Lu, Makoto Miyagishi, Tatsuhiko Kodama, Kenya Honda, Yusuke Ohba & Tadatsugu Taniguchi
doi:10.1038/nature06013
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Career Views
Naturejobs
ProspectProspect p507
Will new data suggest ways for PhD students to shorten their time to degree?
Gene Russo
doi:10.1038/nj7152-507a
Career Views
Gerd Kempermann, professor, Center for Regenerative Therapies, Dresden, Germany p508
Stem-cell scientist moves to new centre in Germany.
Virginia Gewin
doi:10.1038/nj7152-508a
Order of merit p508
There's a better way to determine authorship order.
Christine Beveridge & Suzanne Morris
doi:10.1038/nj7152-508b
Isolation p508
Maternity leave makes me miss the lab.
Moira Sheehan
doi:10.1038/nj7152-508c
