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A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum

Nature volume 448, pages 435–438 (2007)Cite this article

Abstract

Lipids are not encoded by a DNA template and therefore cannot be mutated, knocked out or knocked down. This by no means renders them impotent from a cell biological perspective. Here I propose a model for the involvement of lipid rearrangements in the execution of crucial steps in (glyco)protein quality control.

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Figure 1: Biogenesis of lipid droplets and a model for their involvement in escape of macromolecules and viruses from the ER.

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Acknowledgements

I thank E. Klemm, J. Loureiro and B. Mueller, as well as D. Hoekstra and G. van Meer, for discussions. I thank T. Di Cesare for the artwork.

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  1. MIT Department of Biology, Whitehead Institute, Cambridge, Massachusetts 02142, USA,

    Hidde L. Ploegh

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Correspondence to Hidde L. Ploegh.

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Ploegh, H. A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum. Nature 448, 435–438 (2007). https://doi.org/10.1038/nature06004

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