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News and Views
Nature 448, 416-418 (26 July 2007) | doi:10.1038/448416a; Published online 25 July 2007
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Immunology: Narcissistic helpers
Matthew T. Palmer1 & Casey T. Weaver1
Abstract
T helper-17 cells, which are involved in immune responses, arise from a pool of precursor cells. It emerges that their differentiation is partly mediated by the IL-21 protein, which originates from the helper cells themselves.
Over the past 500 million years, vertebrates have evolved an elegant solution to the lifelong challenge posed by microbes: adaptive immunity. The adaptive immune response is triggered when a foreign, or non-self, molecule (an antigen) is encountered.
- Matthew T. Palmer and Casey T. Weaver are in the Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294-2170, USA.
Email: cweaver@uab.edu
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