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DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

Akinori Takaoka, ZhiChao Wang, Myoung Kwon Choi, Hideyuki Yanai, Hideo Negishi, Tatsuma Ban, Yan Lu, Makoto Miyagishi, Tatsuhiko Kodama, Kenya Honda, Yusuke Ohba & Tadatsugu Taniguchi

Nature 448, 501-505(26 July 2007)

doi:10.1038/nature06013

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

DAI (DLM-1/ZBP1) is a positive regulator for type I IFN induction by cytosolic DNA.

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Figure 2 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 2

DAI (DLM-1/ZBP1) is critical for B-DNA-mediated IRF3 activation and Ifnb mRNA expression.

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Figure 3 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 3

Interaction of DAI (DLM-1/ZBP1) with B-DNA in the cytoplasm.

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Figure 4 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 4

Interaction of DAI (DLM-1/ZBP1) with IRF3 and TBK1.

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