Figures and Tables

From the following article:

Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination

Shalina S. Ousman, Beren H. Tomooka, Johannes M. van Noort, Eric F. Wawrousek, Kevin O'Conner, David A. Hafler, Raymond A. Sobel, William H. Robinson & Lawrence Steinman

Nature 448, 474-479(26 July 2007)

doi:10.1038/nature05935

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Figure 1

Worse EAE, increased immune activation and glial apoptosis in Cryab-/- mice.

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Figure 2

T cells from Cryab-/- EAE mice are hyper-responsive.

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Figure 3

Macrophages deficient in Cryab are hyperactive.

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Figure 4

Cryab-/- astrocytes are more susceptible to cell death and augment ERK and NF-kappaB signalling.

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Figure 5

Myelin antigen array analysis demonstrates antibody targeting of CRYAB in RRMS patients.

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Figure 6

CRYAB suppresses disease and inflammation in EAE.

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Table 1

Quantification of inflammatory foci and TUNEL-positive (TUNEL+) cells in brain and spinal cord samples of wild-type and Cryab-/- mice with EAE

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Table 2

Quantification of inflammatory foci and TUNEL-positive (TUNEL+) cells in brain and spinal cord samples of wild-type mice with EAE treated with PBS or recombinant human CRYAB

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