Figures and Tables

From the following article:

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

John D. Carpten, Andrew L. Faber, Candice Horn, Gregory P. Donoho, Stephen L. Briggs, Christiane M. Robbins, Galen Hostetter, Sophie Boguslawski, Tracy Y. Moses, Stephanie Savage, Mark Uhlik, Aimin Lin, Jian Du, Yue-Wei Qian, Douglas J. Zeckner, Greg Tucker-Kellogg, Jeffrey Touchman, Ketan Patel, Spyro Mousses, Michael Bittner, Richard Schevitz, Mei-Huei T. Lai, Kerry L. Blanchard & James E. Thomas

Nature 448, 439-444(26 July 2007)

doi:10.1038/nature05933

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

Lys 17 alters the apo and Ins(1,3,4,5)P4-complexed AKT1 PHD structure.

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Figure 2

The E17K mutation increases AKT1 activation in NIH 3T3 cells.

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Figure 3

The E17K mutation alters AKT1 cellular localization.

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Figure 4

Transformation of Rat1 fibroblasts by AKT1(E17K).

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Figure 5

Timing and signature of AKT1(E17K)-driven leukaemia.

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