Editor's Summary
26 July 2007
AKT1 as cancer trigger
The AKT/protein kinase B signalling pathway regulates cell proliferation and growth and is involved in cellular processes, including apoptosis and glucose metabolism. While activating mutations in other pathway components have been found, no cancer-activating AKT point mutations were known. But now a mutation in AKT1 has been found in human breast, colorectal and ovarian cancers which activates this kinase by enhancing its membrane association, implicating AKT1 directly in cancer causation.
Article: A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
John D. Carpten, Andrew L. Faber, Candice Horn, Gregory P. Donoho, Stephen L. Briggs, Christiane M. Robbins, Galen Hostetter, Sophie Boguslawski, Tracy Y. Moses, Stephanie Savage, Mark Uhlik, Aimin Lin, Jian Du, Yue-Wei Qian, Douglas J. Zeckner, Greg Tucker-Kellogg, Jeffrey Touchman, Ketan Patel, Spyro Mousses, Michael Bittner, Richard Schevitz, Mei-Huei T. Lai, Kerry L. Blanchard & James E. Thomas
doi:10.1038/nature05933
Abstract | Full Text | PDF (1,310K) | Supplementary information
