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Nature 448, 358-361 (24 June 2007) | doi:10.1038/nature05946;
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Academic Neuropathologist
- University Hospitals Case Medical Center
- Cleveland, Ohio, USA
Professor
- University of Cincinnati and Cincinnati Children's Research Foundation
- Cincinnati, OH
Rhythmic growth explained by coincidence between internal and external cues
Most organisms use circadian oscillators to coordinate physiological and developmental processes such as growth with predictable daily environmental changes like sunrise and sunset. The importance of such coordination is highlighted by studies showing that circadian dysfunction causes reduced fitness in bacteria and plants, as well as sleep and psychological disorders in humans.
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