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Nature 448, 196-199 (27 June 2007) | doi:10.1038/nature05972;

Open Innovation Challenges

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New cell lines from mouse epiblast share defining features with human embryonic stem cells

The application of human embryonic stem (ES) cells in medicine and biology has an inherent reliance on understanding the starting cell population. Human ES cells differ from mouse ES cells and the specific embryonic origin of both cell types is unclear.

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