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Nature 448, 142-143 (12 July 2007) | doi:10.1038/448142a; Published online 11 July 2007
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Professor of Cognitive Neuroscience
- Karolinska Institute
- Stockholm Sweden
University Full-Professor (W3, Tenure Track)
- University of Münster
- Munster 48149 Germany
Gene transcription: Extending the message
Patrick Cramer1
Abstract
During transcription, RNA polymerase catalyses the addition of nucleotides to the growing RNA chain. High-resolution structural snapshots indicate that the polymerase first identifies its substrate, and then incorporates it.
Life is chemistry — well, at least it is to the molecular biologist. But chemical details remain unclear even for some of the fundamental cellular processes such as gene transcription.
- Patrick Cramer is at the Gene Center Munich, Department of Chemistry and Biochemistry, Ludwig-Maximilians-Universität München, Feodor-Lynen-Stra
e 25, 81377 München, Germany.
Email: cramer@lmb.uni-muenchen.de
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