Figures and Tables

From the following article:

Antitumour drugs impede DNA uncoiling by topoisomerase I

Daniel A. Koster, Komaraiah Palle, Elisa S. M. Bot, Mary-Ann Bjornsti & Nynke H. Dekker

Nature 448, 213-217(12 July 2007)

doi:10.1038/nature05938

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

Drug-dependent slow DNA uncoiling by human TopIB.

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Figure 2

The duration of slow removal and its uniqueness to the removal of positive supercoils.

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Figure 3

Camptothecin poisoning of TopIB induces accumulation of positively supercoiled DNA in G1- and S-phase yeast cells.

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Figure 4

Mechanism of camptothecin-induced toxicity derives from TopIB-dependent accumulation of positive supercoils.

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