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From the following article:

Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J

Clement Y. Chow, Yanling Zhang, James J. Dowling, Natsuko Jin, Maja Adamska, Kensuke Shiga, Kinga Szigeti, Michael E. Shy, Jun Li, Xuebao Zhang, James R. Lupski, Lois S. Weisman & Miriam H. Meisler

Nature 448, 68-72(5 July 2007)

doi:10.1038/nature05876

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

Phenotypes of homozygous pale tremor mice.

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Figure 2

Neuropathology in pale tremor mice.

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Figure 3

Pathological abnormalities in peripheral nerves.

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Figure 4

Mutations of FIG4 in patients with CMT disorder.

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Figure 5

Yeast Fig4Ile > Thr is defective in activation of kinase Fab1/PIKfyve.

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