Table of contents
Volume 447 Number 7147 pp885-1030
In this issue (21 June 2007)
Also this week
(this content only available online) indicates content that is available online only
Editorials
Asia on the rise p885
The balance of scientific power is moving east as scientists in the Asia-Pacific region learn to collaborate more effectively.
doi:10.1038/447885a
Discourse with Iran p886
Academic freedom is under threat, again.
doi:10.1038/447886a
An end in sight p886
Better days ahead for flagship regulator.
doi:10.1038/447886b
News
Academic freedom under threat in Iran p890
Researchers detained on suspicion of 'espionage'
Declan Butler
doi:10.1038/447890a
Monkey stem cells cloned p891
Advance could renew enthusiasm for the field
Monya Baker
doi:10.1038/447891a
Special report
All the King's men p892
Congress requires the Environmental Protection Agency to look after the environment; the Bush administration wants it to be pro-business. Emma Marris steps through the looking glass to profile the result.
doi:10.1038/447892a
Fossils challenge DNA in the dating game p894
Findings revives debate on when modern mammals evolved
John Whitfield
doi:10.1038/447894a
Quarter of deaths from environment are avoidable p894
Evidence should help prioritize disease prevention efforts
Quirin Schiermeier
doi:10.1038/447894b
Sidelines p895
doi:10.1038/447895a
Darwin down but not out p896
World Heritage bid for Darwin's home withdrawn
Henry Nicholls
doi:10.1038/447896a
News in brief p897
doi:10.1038/447897a
Correction p897
doi:10.1038/447897b
Business
Anaemic outlook for Amgen p899
A rash of problems has knocked some of the shine off one of the world's top biotechnology companies, as Meredith Wadman reports.
doi:10.1038/447899a
News Features
Formula 1 racing: Power games p900
Can motor racing go green? Andreas Trabesinger asked Max Mosley, head of Formula 1, how he wants the sport to develop energy-efficient technology that will also work in road cars.
doi:10.1038/447900a
See also: Editor's summary
Extreme culture p905
From acid mine drainage to the bowels of the Earth, Josie Glausiusz reports how researchers are taking great pains to grow recalcitrant bacteria.
doi:10.1038/447905a
See also: Editor's summary
Correspondence
Scientists should promote co-operation, not boycott p908
Bengt Gustafsson
doi:10.1038/447908a
US government enforces boycott of whole countries p908
Sina Zarrintan
doi:10.1038/447908b
Cincinnati's rhino breeders bring home the bacon p908
Martin F. Heyworth
doi:10.1038/447908c
Cooling may be possible, but we need safety data p908
John Latham
doi:10.1038/447908d
Darwin Centre will be fit for its range of purposes p908
Richard Lane
doi:10.1038/447908e
Books and Arts
Weird and wonderful p909
The quantity and diversity of deep-sea life are a match for the rainforests.
Mark Schrope reviews The Deep: The Extraordinary Creatures of the Abyss by Claire Nouvian and The Silent Deep: The Discovery, Ecology and Conservation of the Deep Sea by Tony Koslow
doi:10.1038/447909a
Wonders from down under p910
Colin Martin reviews Continent of Curiosities: A Journey Through Australian Natural History by Danielle Clode
doi:10.1038/447910a
See also: Editor's summary
DNA cycle p911
doi:10.1038/447911a
A golden circle in the sky p911
Raymond T. Pierrehumbert reviews An Ocean of Air : A Natural History of the Atmosphere by Gabrielle Walker
doi:10.1038/447911b
Essay
ConceptEukaryote evolution: Engulfed by speculation p913
The notion that eukaryotes evolved via a merger of cells from the other two domains — archaea and bacteria — overlooks known processes.
Anthony Poole & David Penny
doi:10.1038/447913a
See also: Editor's summary
News and Views
Chemical engineering: Hybrid routes to biofuels p914
Traditional methods for making fuels from biomass come in two forms — biological or chemical. The latest approach combines the best of both worlds, and heralds the advent of a second generation of biofuels.
Lanny D. Schmidt & Paul J. Dauenhauer
doi:10.1038/447914a
See also: Editor's summary
50 & 100 Years Ago p915
doi:10.1038/447915a
Immunology: Short-term memory p916
Chemical modification of histone proteins can affect the expression of their associated genes. Some immune cells seem to exploit this process to avoid excessive inflammation while fighting invading pathogens.
Benjamin N. Gantner & Harinder Singh
doi:10.1038/447916a
Materials science: Reflections on ionic liquids p917
Ionic liquids are generally regarded as solvents, but these modular, tunable compounds have far greater technological potential. With a coat of silver, they become ideal materials for the liquid mirror of a space telescope.
Robin D. Rogers
doi:10.1038/447917a
See also: Editor's summary
Evolutionary biology: Re-crowning mammals p918
The evolutionary history of mammals is being tackled both through molecular analyses and through morphological studies of fossils. The 'molecules versus morphology' debate remains both vexing and vibrant.
Richard L. Cifelli & Cynthia L. Gordon
doi:10.1038/447918a
See also: Editor's summary
Biophysics: Proteins hunt and gather p920
Some proteins do not fold fully until they meet their functional partners. Folding in concert with binding allows an efficient stepwise search for the proper structure within the final complex.
David Eliezer & Arthur G. Palmer, III
doi:10.1038/447920a
Structural biology: ESCRT service p921
The sorting and degradation of cell-surface proteins are essential for cellular homeostasis. The ESCRT-I complex is known to be involved in these events, and new structural findings elucidate its core architecture.
Steven L. Alam & Wesley I. Sundquist
doi:10.1038/447921a
Insight: DNA replication and repair -
Insight: DNA replication and repair
DNA replication and repair p923
Angela K. Eggleston
doi:10.1038/447923a
Replication and protection of telomeres p924
Ramiro E. Verdun & Jan Karlseder
doi:10.1038/nature05976
Abstract | Full Text | PDF (704K)
Expandable DNA repeats and human disease p932
Sergei M. Mirkin
doi:10.1038/nature05977
Abstract | Full Text | PDF (644K)
Base-excision repair of oxidative DNA damage p941
Sheila S. David, Valerie L. O'Shea & Sucharita Kundu
doi:10.1038/nature05978
Abstract | Full Text | PDF (1,003K)
Chromatin dynamics and the preservation of genetic information p951
Jessica A. Downs, Michel C. Nussenzweig & André Nussenzweig
doi:10.1038/nature05980
Abstract | Full Text | PDF (893K)
Articles
Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2 p959
Masato Furuhashi, Gürol Tuncman, Cem Z. Görgün, Liza Makowski, Genichi Atsumi, Eric Vaillancourt, Keita Kono, Vladimir R. Babaev, Sergio Fazio, MacRae F. Linton, Richard Sulsky, Jeffrey A. Robl, Rex A. Parker & Gökhan S. Hotamisligil
doi:10.1038/nature05844
Abstract | Full Text | PDF (782K) | Supplementary information
See also: Editor's summary
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers p966
Richard S. Maser, Bhudipa Choudhury, Peter J. Campbell, Bin Feng, Kwok-Kin Wong, Alexei Protopopov, Jennifer O'Neil, Alejandro Gutierrez, Elena Ivanova, Ilana Perna, Eric Lin, Vidya Mani, Shan Jiang, Kate McNamara, Sara Zaghlul, Sarah Edkins, Claire Stevens, Cameron Brennan, Eric S. Martin, Ruprecht Wiedemeyer, Omar Kabbarah, Cristina Nogueira, Gavin Histen, Jon Aster, Marc Mansour, Veronique Duke, Letizia Foroni, Adele K. Fielding, Anthony H. Goldstone, Jacob M. Rowe, Yaoqi A. Wang, A. Thomas Look, Michael R. Stratton, Lynda Chin, P. Andrew Futreal & Ronald A. DePinho
doi:10.1038/nature05886
Abstract | Full Text | PDF (767K) | Supplementary information
See also: Editor's summary
Gene-specific control of inflammation by TLR-induced chromatin modifications p972
Simmie L. Foster, Diana C. Hargreaves & Ruslan Medzhitov
doi:10.1038/nature05836
Abstract | Full Text | PDF (685K) | Supplementary information
See also: News and Views by Gantner & Singh
Letters
Deposition of metal films on an ionic liquid as a basis for a lunar telescope p979
Ermanno F. Borra, Omar Seddiki, Roger Angel, Daniel Eisenstein, Paul Hickson, Kenneth R. Seddon & Simon P. Worden
doi:10.1038/nature05909
First paragraph | Full Text | PDF (275K) | Supplementary information
See also: Editor's summary | News and Views by Rogers
Production of dimethylfuran for liquid fuels from biomass-derived carbohydrates p982
Yuriy Román-Leshkov, Christopher J. Barrett, Zhen Y. Liu & James A. Dumesic
doi:10.1038/nature05923
First paragraph | Full Text | PDF (300K) | Supplementary information
See also: Editor's summary | News and Views by Schmidt & Dauenhauer
The early Miocene onset of a ventilated circulation regime in the Arctic Ocean p986
Martin Jakobsson, Jan Backman, Bert Rudels, Jonas Nycander, Martin Frank, Larry Mayer, Wilfried Jokat, Francesca Sangiorgi, Matthew O'Regan, Henk Brinkhuis, John King & Kathryn Moran
doi:10.1038/nature05924
First paragraph | Full Text | PDF (897K) | Supplementary information
See also: Editor's summary
Electromagnetic detection of a 410-km-deep melt layer in the southwestern United States p991
Daniel A. Toffelmier & James A. Tyburczy
doi:10.1038/nature05922
First paragraph | Full Text | PDF (320K) | Supplementary information
See also: Editor's summary
Recuperation of nitrogen cycling in Amazonian forests following agricultural abandonment p995
Eric A. Davidson, Cláudio J. Reis de Carvalho, Adelaine Michela Figueira, Françoise Yoko Ishida, Jean Pierre H. B. Ometto, Gabriela B. Nardoto, Renata Tuma Sabá, Sanae N. Hayashi, Eliane C. Leal, Ima Célia G. Vieira & Luiz A. Martinelli
doi:10.1038/nature05900
First paragraph | Full Text | PDF (187K) | Supplementary information
See also: Editor's summary
The significance of nitrification for oceanic new production p999
Andrew Yool, Adrian P. Martin, Camila Fernández & Darren R. Clark
doi:10.1038/nature05885
First paragraph | Full Text | PDF (494K) | Supplementary information
See also: Editor's summary
Cretaceous eutherians and Laurasian origin for placental mammals near the K/T boundary p1003
J. R. Wible, G. W. Rougier, M. J. Novacek & R. J. Asher
doi:10.1038/nature05854
First paragraph | Full Text | PDF (822K) | Supplementary information
See also: Editor's summary | News and Views by Cifelli & Gordon
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis p1007
Trista E. North, Wolfram Goessling, Carl R. Walkley, Claudia Lengerke, Kamden R. Kopani, Allegra M. Lord, Gerhard J. Weber, Teresa V. Bowman, Il-Ho Jang, Tilo Grosser, Garret A. FitzGerald, George Q. Daley, Stuart H. Orkin & Leonard I. Zon
doi:10.1038/nature05883
First paragraph | Full Text | PDF (691K) | Supplementary information
See also: Editor's summary
Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1
transcription coactivator p1012
Xinghai Li, Bobby Monks, Qingyuan Ge & Morris J. Birnbaum
doi:10.1038/nature05861
First paragraph | Full Text | PDF (626K) | Supplementary information
Energy-dependent regulation of cell structure by AMP-activated protein kinase p1017
Jun Hee Lee, Hyongjong Koh, Myungjin Kim, Yongsung Kim, Soo Young Lee, Roger E. Karess, Sang-Hee Lee, Minho Shong, Jin-Man Kim, Jaeseob Kim & Jongkyeong Chung
doi:10.1038/nature05828
First paragraph | Full Text | PDF (1,453K) | Supplementary information
Mechanism of coupled folding and binding of an intrinsically disordered protein p1021
Kenji Sugase, H. Jane Dyson & Peter E. Wright
doi:10.1038/nature05858
First paragraph | Full Text | PDF (749K) | Supplementary information
See also: News and Views by Eliezer & Palmer
Naturejobs
ProspectThe importance of going green in the lab p1027
Gene Russo
doi:10.1038/nj7147-1027a
Career Views
Andreas Meyer-Lindenberg, director, Central Institute of Mental Health, Mannheim, Germany p1028
Neuroscientist leaves NIH to head back to native Germany
Virginia Gewin
doi:10.1038/nj7147-1028a
Employing Japan's postdocs p1028
Japanese postdocs face career challenges
Yasuo Kanamatsu & Kyoko Takahashi
doi:10.1038/nj7147-1028b
Growth p1028
I'm trying to thrive in whatever environment I end up in
Maria Ocampo-Hafalla
doi:10.1038/nj7147-1028c
Recruiters
Time to make haste p1030
Scientists with a busy schedule must free up time to develop professionally in a fast-moving sector.
Deb Koen
doi:10.1038/nj7147-1030a
Highlights
Opportunities: The National Institutes of Health
doi:10.1038/nj0162
Highlight: Texas
doi:10.1038/nj0163