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Nature 447, 941-950 (21 June 2007) | doi:10.1038/nature05978; Published online 20 June 2007
Open Innovation Challenges
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Fast Growth of Transformed Soybean Shoots
A method for accelerating growth of soybean shoots is desired.
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Protect Enzyme from In Planta Degradation
A proposal for stable expression of an enzyme in corn seed is desired.
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Three Associate Senior Lecturer positions within Natural Sciences
- The University of Kalmar
- Kalmar, Sweden
Scientist, Recombinant Protein Expression
- Novo Nordisk Foundation Center for Protein Research, University of Copenhagen
- Copenhagen 2200 Denmark
Review Article Base-excision repair of oxidative DNA damage
Sheila S. David1, Valerie L. O'Shea2 & Sucharita Kundu2
Abstract
Maintaining the chemical integrity of DNA in the face of assault by oxidizing agents is a constant challenge for living organisms. Base-excision repair has an important role in preventing mutations associated with a common product of oxidative damage to DNA, 8-oxoguanine. Recent structural studies have shown that 8-oxoguanine DNA glycosylases use an intricate series of steps to locate and excise 8-oxoguanine lesions efficiently against a high background of undamaged bases. The importance of preventing mutations associated with 8-oxoguanine is shown by a direct association between defects in the DNA glycosylase MUTYH and colorectal cancer. The properties of other guanine oxidation products and the associated DNA glycosylases that remove them are now also being revealed.
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