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Nature 447, 923 (21 June 2007) | doi:10.1038/447923a; Published online 20 June 2007

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Introduction DNA replication and repair

Angela K. Eggleston1

In the beginning, there was nucleic acid. Evolutionary biologists have argued persuasively that nucleic acids were the original self-replicating entity, an idea encapsulated in the RNA-world hypothesis.