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From the following article:

Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures

Katharina Zimmermann, Andreas Leffler, Alexandru Babes, Cruz Miguel Cendan, Richard W. Carr, Jin-ichi Kobayashi, Carla Nau, John N. Wood & Peter W. Reeh

Nature 447, 856-859(14 June 2007)

doi:10.1038/nature05880

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Figure 1

TTX-blocked sensory C-fibre terminals regain responsiveness on cooling.

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Figure 2

Low temperature differentially affects TTXs and TTXr VGSCs.

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Figure 3

Loss of Nav1.8 impairs responsiveness to noxious stimulation in the cold.

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Figure 4

Cooling increases TTXr excitability in nociceptive terminals.

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