Provider: Nature Publishing Group Content: application/x-research-info-systems TY - JOUR AU - Schlessinger, D. AU - Van Zant, G. TI - Does functional depletion of stem cells drive aging? JA - Mech. Ageing Dev. PY - 2001/// VL - 122 SP - 1537 EP - 1553 M3 - 10.1016/S0047-6374(01)00299-8 N1 - 10.1016/S0047-6374(01)00299-8 UR - http://dx.doi.org/10.1016/S0047-6374(01)00299-8 ER - TY - JOUR AU - Park, Y. AU - Gerson, S. L. TI - DNA repair defects in stem cell function and aging JA - Annu. Rev. Med. PY - 2005/// VL - 56 SP - 495 EP - 508 M3 - 10.1146/annurev.med.56.082103.104546 N1 - 10.1146/annurev.med.56.082103.104546 UR - http://dx.doi.org/10.1146/annurev.med.56.082103.104546 ER - TY - JOUR AU - de Boer, J. TI - A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophy JA - Mol. Cell PY - 1998/// VL - 1 SP - 981 EP - 990 M3 - 10.1016/S1097-2765(00)80098-2 N1 - 10.1016/S1097-2765(00)80098-2 UR - http://dx.doi.org/10.1016/S1097-2765(00)80098-2 ER - TY - JOUR AU - de Boer, J. TI - Premature aging in mice deficient in DNA repair and transcription JA - Science PY - 2002/// VL - 296 SP - 1276 EP - 1279 M3 - 10.1126/science.1070174 N1 - 10.1126/science.1070174 UR - http://dx.doi.org/10.1126/science.1070174 ER - TY - JOUR AU - Blasco, M. A. TI - Telomere shortening and tumor formation by mouse cells lacking telomerase RNA JA - Cell PY - 1997/// VL - 91 SP - 25 EP - 34 M3 - 10.1016/S0092-8674(01)80006-4 N1 - 10.1016/S0092-8674(01)80006-4 UR - http://dx.doi.org/10.1016/S0092-8674(01)80006-4 ER - TY - JOUR AU - Rudolph, K. L. TI - Longevity, stress response, and cancer in aging telomerase-deficient mice JA - Cell PY - 1999/// VL - 96 SP - 701 EP - 712 M3 - 10.1016/S0092-8674(00)80580-2 N1 - 10.1016/S0092-8674(00)80580-2 UR - http://dx.doi.org/10.1016/S0092-8674(00)80580-2 ER - TY - JOUR AU - Nussenzweig, A. TI - Requirement for Ku80 in growth and immunoglobulin V(D)J recombination JA - Nature PY - 1996/// VL - 382 SP - 551 EP - 555 M3 - 10.1038/382551a0 N1 - 10.1038/382551a0 UR - http://dx.doi.org/10.1038/382551a0 ER - TY - JOUR AU - Nussenzweig, A. AU - Sokol, K. AU - Burgman, P. AU - Li, L. AU - Li, G. C. TI - Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: the effects of ionizing radiation on growth, survival, and development JA - Proc. Natl Acad. Sci. USA PY - 1997/// VL - 94 SP - 13588 EP - 13593 M3 - 10.1073/pnas.94.25.13588 N1 - 10.1073/pnas.94.25.13588 UR - http://dx.doi.org/10.1073/pnas.94.25.13588 ER - TY - JOUR AU - Rossi, D. J. TI - Cell intrinsic alterations underlie hematopoietic stem cell aging JA - Proc. Natl Acad. Sci. USA PY - 2005/// VL - 102 SP - 9194 EP - 9199 M3 - 10.1073/pnas.0503280102 N1 - 10.1073/pnas.0503280102 UR - http://dx.doi.org/10.1073/pnas.0503280102 ER - TY - JOUR AU - Sudo, K. AU - Ema, H. AU - Morita, Y. AU - Nakauchi, H. TI - Age-associated characteristics of murine hematopoietic stem cells JA - J. Exp. Med. PY - 2000/// VL - 192 SP - 1273 EP - 1280 M3 - 10.1084/jem.192.9.1273 N1 - 10.1084/jem.192.9.1273 UR - http://dx.doi.org/10.1084/jem.192.9.1273 ER - TY - JOUR AU - Morrison, S. J. AU - Wandycz, A. M. AU - Akashi, K. AU - Globerson, A. AU - Weissman, I. L. TI - The aging of hematopoietic stem cells JA - Nature Med. PY - 1996/// VL - 2 SP - 1011 EP - 1016 M3 - 10.1038/nm0996-1011 N1 - 10.1038/nm0996-1011 UR - http://dx.doi.org/10.1038/nm0996-1011 ER - TY - JOUR AU - Bryder, D. AU - Rossi, D. J. AU - Weissman, I. L. TI - Hematopoietic stem cells: the paradigmatic tissue-specific stem cell JA - Am. J. Pathol. PY - 2006/// VL - 169 SP - 338 EP - 346 M3 - 10.2353/ajpath.2006.060312 N1 - 10.2353/ajpath.2006.060312 UR - http://dx.doi.org/10.2353/ajpath.2006.060312 ER - TY - JOUR AU - Yamazaki, S. TI - Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells JA - EMBO J. PY - 2006/// VL - 25 SP - 3515 EP - 3523 M3 - 10.1038/sj.emboj.7601236 N1 - 10.1038/sj.emboj.7601236 UR - http://dx.doi.org/10.1038/sj.emboj.7601236 ER - TY - JOUR AU - Passegue, E. AU - Wagers, A. J. AU - Giuriato, S. AU - Anderson, W. C. AU - Weissman, I. L. TI - Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates JA - J. Exp. Med. PY - 2005/// VL - 202 SP - 1599 EP - 1611 M3 - 10.1084/jem.20050967 N1 - 10.1084/jem.20050967 UR - http://dx.doi.org/10.1084/jem.20050967 ER - TY - JOUR AU - Ishikawa, K. AU - Ishii, H. AU - Saito, T. TI - DNA damage-dependent cell cycle checkpoints and genomic stability JA - DNA Cell Biol. PY - 2006/// VL - 25 SP - 406 EP - 411 M3 - 10.1089/dna.2006.25.406 N1 - 10.1089/dna.2006.25.406 UR - http://dx.doi.org/10.1089/dna.2006.25.406 ER - TY - JOUR AU - Allsopp, R. C. AU - Morin, G. B. AU - DePinho, R. AU - Harley, C. B. AU - Weissman, I. L. TI - Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation JA - Blood PY - 2003/// VL - 102 SP - 517 EP - 520 M3 - 10.1182/blood-2002-07-2334 N1 - 10.1182/blood-2002-07-2334 UR - http://dx.doi.org/10.1182/blood-2002-07-2334 ER - TY - JOUR AU - Samper, E. TI - Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells JA - Blood PY - 2002/// VL - 99 SP - 2767 EP - 2775 M3 - 10.1182/blood.V99.8.2767 N1 - 10.1182/blood.V99.8.2767 UR - http://dx.doi.org/10.1182/blood.V99.8.2767 ER - TY - JOUR AU - Choudhury, A. R. TI - Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation JA - Nature Genet. PY - 2007/// VL - 39 SP - 99 EP - 105 M3 - 10.1038/ng1937 N1 - 10.1038/ng1937 UR - http://dx.doi.org/10.1038/ng1937 ER - TY - JOUR AU - Domen, J. AU - Cheshier, S. H. AU - Weissman, I. L. TI - The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of Bcl-2 increases both their number and repopulation potential JA - J. Exp. Med. PY - 2000/// VL - 191 SP - 253 EP - 264 M3 - 10.1084/jem.191.2.253 N1 - 10.1084/jem.191.2.253 UR - http://dx.doi.org/10.1084/jem.191.2.253 ER - TY - JOUR AU - Rogakou, E. P. AU - Pilch, D. R. AU - Orr, A. H. AU - Ivanova, V. S. AU - Bonner, W. M. TI - DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139 JA - J. Biol. Chem. PY - 1998/// VL - 273 SP - 5858 EP - 5868 M3 - 10.1074/jbc.273.10.5858 N1 - 10.1074/jbc.273.10.5858 UR - http://dx.doi.org/10.1074/jbc.273.10.5858 ER - TY - JOUR AU - Kim, M. AU - Moon, H. B. AU - Spangrude, G. J. TI - Major age-related changes of mouse hematopoietic stem/progenitor cells JA - Ann. NY Acad. Sci. PY - 2003/// VL - 996 SP - 195 EP - 208 ER - TY - JOUR AU - Kirkwood, T. B. TI - Understanding the odd science of aging JA - Cell PY - 2005/// VL - 120 SP - 437 EP - 447 M3 - 10.1016/j.cell.2005.01.027 N1 - 10.1016/j.cell.2005.01.027 UR - http://dx.doi.org/10.1016/j.cell.2005.01.027 ER - TY - JOUR AU - Navarro, S. TI - Hematopoietic dysfunction in a mouse model for Fanconi anemia group D1 JA - Mol. Ther. PY - 2006/// VL - 14 SP - 525 EP - 535 M3 - 10.1016/j.ymthe.2006.05.018 N1 - 10.1016/j.ymthe.2006.05.018 UR - http://dx.doi.org/10.1016/j.ymthe.2006.05.018 ER - TY - JOUR AU - Reese, J. S. AU - Liu, L. AU - Gerson, S. L. TI - Repopulating defect of mismatch repair-deficient hematopoietic stem cells JA - Blood PY - 2003/// VL - 102 SP - 1626 EP - 1633 M3 - 10.1182/blood-2002-10-3035 N1 - 10.1182/blood-2002-10-3035 UR - http://dx.doi.org/10.1182/blood-2002-10-3035 ER - TY - JOUR AU - Prasher, J. M. TI - Reduced hematopoietic reserves in DNA interstrand crosslink repair-deficient Ercc1-/- mice JA - EMBO J. PY - 2005/// VL - 24 SP - 861 EP - 871 M3 - 10.1038/sj.emboj.7600542 N1 - 10.1038/sj.emboj.7600542 UR - http://dx.doi.org/10.1038/sj.emboj.7600542 ER - TY - JOUR AU - Ito, K. TI - Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells JA - Nature PY - 2004/// VL - 431 SP - 997 EP - 1002 M3 - 10.1038/nature02989 N1 - 10.1038/nature02989 UR - http://dx.doi.org/10.1038/nature02989 ER - TY - JOUR AU - Ito, K. TI - Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells JA - Nature Med. PY - 2006/// VL - 12 SP - 446 EP - 451 M3 - 10.1038/nm1388 N1 - 10.1038/nm1388 UR - http://dx.doi.org/10.1038/nm1388 ER - TY - JOUR AU - Bender, C. F. TI - Cancer predisposition and hematopoietic failure in Rad50S/S mice JA - Genes Dev. PY - 2002/// VL - 16 SP - 2237 EP - 2251 M3 - 10.1101/gad.1007902 N1 - 10.1101/gad.1007902 UR - http://dx.doi.org/10.1101/gad.1007902 ER - TY - JOUR AU - Morales, M. TI - The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor JA - Genes Dev. PY - 2005/// VL - 19 SP - 3043 EP - 3054 M3 - 10.1101/gad.1373705 N1 - 10.1101/gad.1373705 UR - http://dx.doi.org/10.1101/gad.1373705 ER - TY - JOUR AU - Seita, J. TI - Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction JA - Proc. Natl Acad. Sci. USA PY - 2007/// VL - 104 SP - 2349 EP - 2354 M3 - 10.1073/pnas.0606238104 N1 - 10.1073/pnas.0606238104 UR - http://dx.doi.org/10.1073/pnas.0606238104 ER - TY - JOUR AU - de Boer, J. TI - A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophy JA - Mol. Cell PY - 1998/// VL - 1 SP - 981 EP - 990 M3 - 10.1016/S1097-2765(00)80098-2 N1 - 10.1016/S1097-2765(00)80098-2 UR - http://dx.doi.org/10.1016/S1097-2765(00)80098-2 ER - TY - JOUR AU - de Boer, J. TI - Premature ageing in mice deficient in DNA repair and transcription JA - Science PY - 2002/// VL - 296 SP - 1276 EP - 1279 M3 - 10.1126/science.1070174 N1 - 10.1126/science.1070174 UR - http://dx.doi.org/10.1126/science.1070174 ER - TY - JOUR AU - Nussenzweig, A. TI - Requirement for Ku80 in growth and immunoglobulin V(D)J recombination JA - Nature PY - 1996/// VL - 382 SP - 551 EP - 555 M3 - 10.1038/382551a0 N1 - 10.1038/382551a0 UR - http://dx.doi.org/10.1038/382551a0 ER - TY - JOUR AU - Nussenzweig, A. AU - Sokol, K. AU - Burgman, P. AU - Li, L. AU - Li, G. C. TI - Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: the effects of ionizing radiation on growth, survival, and development JA - Proc. Natl Acad. Sci. USA PY - 1997/// VL - 94 SP - 13588 EP - 13593 M3 - 10.1073/pnas.94.25.13588 N1 - 10.1073/pnas.94.25.13588 UR - http://dx.doi.org/10.1073/pnas.94.25.13588 ER - TY - JOUR AU - Difilippantonio, M. J. TI - DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation JA - Nature PY - 2000/// VL - 404 SP - 510 EP - 514 M3 - 10.1038/35006670 N1 - 10.1038/35006670 UR - http://dx.doi.org/10.1038/35006670 ER - TY - JOUR AU - Rudolph, K. L. TI - Longevity, stress response, and cancer in aging telomerase-deficient mice JA - Cell PY - 1999/// VL - 96 SP - 701 EP - 712 M3 - 10.1016/S0092-8674(00)80580-2 N1 - 10.1016/S0092-8674(00)80580-2 UR - http://dx.doi.org/10.1016/S0092-8674(00)80580-2 ER - TY - JOUR AU - Blasco, M. A. TI - Telomere shortening and tumour formation by mouse cells lacking telomerase RNA JA - Cell PY - 1997/// VL - 91 SP - 25 EP - 34 M3 - 10.1016/S0092-8674(01)80006-4 N1 - 10.1016/S0092-8674(01)80006-4 UR - http://dx.doi.org/10.1016/S0092-8674(01)80006-4 ER - TY - JOUR AU - Lee, H. W. TI - Essential role of mouse telomerase in highly proliferative organs JA - Nature PY - 1998/// VL - 392 SP - 569 EP - 574 M3 - 10.1038/33345 N1 - 10.1038/33345 UR - http://dx.doi.org/10.1038/33345 ER - TY - JOUR AU - Hathcock, K. S. TI - Haploinsufficiency of mTR results in defects in telomere elongation JA - Proc. Natl Acad. Sci. USA PY - 2002/// VL - 99 SP - 3591 EP - 3596 M3 - 10.1073/PNAS.012549799 N1 - 10.1073/PNAS.012549799 UR - http://dx.doi.org/10.1073/PNAS.012549799 ER - TY - JOUR AU - Allsopp, R. C. AU - Cheshier, S. AU - Weissman, I. L. TI - Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cells JA - J. Exp. Med. PY - 2001/// VL - 193 SP - 917 EP - 924 M3 - 10.1084/JEM.193.8.917 N1 - 10.1084/JEM.193.8.917 UR - http://dx.doi.org/10.1084/JEM.193.8.917 ER - TY - JOUR AU - Herrera, E. TI - Disease states associated with telomerase deficiency appear earlier in mice with short telomeres JA - EMBO J. PY - 1999/// VL - 18 SP - 2950 EP - 2960 M3 - 10.1093/emboj/18.11.2950 N1 - 10.1093/emboj/18.11.2950 UR - http://dx.doi.org/10.1093/emboj/18.11.2950 ER - TY - GEN AU - Rossi, D. J. TI - Cell intrinsic alterations underlie haematopoietic stem cell ageing PY - 2005/// SP - 9194 EP - 9199 ER -