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From the following article:

DNA repair is limiting for haematopoietic stem cells during ageing

Anastasia Nijnik, Lisa Woodbine, Caterina Marchetti, Sara Dawson, Teresa Lambe, Cong Liu, Neil P. Rodrigues, Tanya L. Crockford, Erik Cabuy, Alessandro Vindigni, Tariq Enver, John I. Bell, Predrag Slijepcevic, Christopher C. Goodnow, Penelope A. Jeggo & Richard J. Cornall

Nature 447, 686-690(7 June 2007)

doi:10.1038/nature05875

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Figure 1

Identification of an ENU-induced missense substitution in LigIV in the tiny mouse strain.

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Figure 2

Impact of the Y288C mutation.

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Figure 3

Double-strand breaks accumulate in Lig4Y288C embryonic fibroblasts independently of replication and confer impaired proliferation.

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Figure 4

Lig4Y288C impairs the maintenance of adult haematopoietic stem cells.

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Figure 5

Lig4Y288C impairs the intrinsic function of adult haematopoietic stem cells.

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