FIGURE 1. Identification of an ENU-induced missense substitution in LigIV in the tiny mouse strain.
From the following article:
DNA repair is limiting for haematopoietic stem cells during ageing
Anastasia Nijnik, Lisa Woodbine, Caterina Marchetti, Sara Dawson, Teresa Lambe, Cong Liu, Neil P. Rodrigues, Tanya L. Crockford, Erik Cabuy, Alessandro Vindigni, Tariq Enver, John I. Bell, Predrag Slijepcevic, Christopher C. Goodnow, Penelope A. Jeggo & Richard J. Cornall
Nature 447, 686-690(7 June 2007)
doi:10.1038/nature05875
a, Flow cytometry of blood, stained for B220 and CD4, from B6 wild-type (WT) and Lig4Y288C homozygous mice. b, c, Weight (b) and size (c) of 8-week-old sex-matched Lig4Y288C homozygous and wild-type B6 littermates (means and 95% confidence intervals are shown in b). d, Mapping the phenotype to chromosome 8. e, A1067G substitution in Lig4 cDNA. f, Location of the mutation in the domain structure of LigIV.
