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Nature 447, 513 (31 May 2007) | doi:10.1038/447513a; Published online 30 May 2007

Man on a mission

Meredith Wadman

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A look at the world of Steven Nissen, the cardiologist who raised worries about Vioxx and Avandia.

It isn't every clinical scientist who in the space of a month sends a major drug company's stock plummeting, is invited to testify at Congress and is crowned one of the world's 100 most influential people by Time magazine. But then, they aren't Steven Nissen, the cardiologist who last week fingered the diabetes drug Avandia as carrying a possible risk of heart attacks (see Weighing up the evidence).