Supplementary information

From the following article:

Aggregation and vesiculation of membrane proteins by curvature-mediated interactions

Benedict J. Reynwar, Gregoria Illya, Vagelis A. Harmandaris, Martin M. Müller, Kurt Kremer & Markus Deserno

Nature 447, 461-464(24 May 2007)

doi:10.1038/nature05840

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Supplementary Information

This file contains Supplementary Methods, Supplementary Discussion, Supplementary Figure 1 illustrating the pair-correlation function of the small and large caps, Supplementary Table 1 presenting parameters of non-bonded interactions, Supplementary Videos Legends and additional references.

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Supplementary Video 1

This file contains Supplementary Video 1 which shows vesiculation event driven by 36 large caps (see Figure 1) on a membrane containing 46 080 lipids. First, only membrane fluctuations and clustering of the caps are visible, then after 40 000 zeta a large protein aggregate buckles the membrane and the formation of a bud is observed. The movie length is 70 700 zeta ~ 1 ms.

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Supplementary Video 2

This file contains Supplementary Video 2 which shows vesiculation event driven by 36 extra large caps on a membrane containing 46 080 lipids. The caps are constructed from two layers of 106 particles which is about twice the number as the large caps in Movie S1. Aggregation of the caps into small buds can be seen. At the end of the movie, the membrane is peeled away so that the buds can be clearly seen. The movie length is 16 700 zeta ~ 0.25 ms.

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Supplementary Video 3

This file contains Supplementary Video 3 which shows cooperative budding driven by 16 capsids on a membrane containing 40 960 lipids. The formation of capsid pairs is seen, followed by the budding of clusters of 3 or 4 capsids. At the end of the movie the membrane is peeled away so that the buds can be clearly seen. The movie length is 39 800 zeta ~ 0.6 ms.

Download Movie (24.1MB)

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