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Nature 447, 389-390 (24 May 2007) | doi:10.1038/447389a; Published online 23 May 2007
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Assistant / Associate
- University of Missouri
- Columbia MO 65211 United States
Postdoctoral Position
- University of Kentucky
- Lexi ngton, Kentucky
Molecular medicine: MicroRNAs and the tell-tale heart
Kenneth R. Chien1
Abstract
MicroRNAs are natural, single-stranded, small RNA molecules thought to control gene expression. Four studies indicate that specific microRNA sequences can regulate heart function in development and disease.
Understanding how complex physiological processes are coordinately controlled at the molecular level in vivo is one of the cornerstones of research in modern translational (bench-to-bedside) medicine. Using the heart as a model physiological system, four research teams1, 2, 3, 4 now establish a role for microRNAs (miRNAs or miRs) in the regulation of in vivo cardiac function: specifically, the conductance of electrical signals, heart muscle contraction, and heart growth and morphogenesis.
- Kenneth R. Chien is in the MGH Cardiovascular Research Center, Department of Cell Biology, Harvard Medical School and the Harvard Stem Cell Institute, Boston, Massachusetts 02114, USA.
Email: kchien@partners.org
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