Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature 447, 389-390 (24 May 2007) | doi:10.1038/447389a; Published online 23 May 2007
Open Innovation Challenges
-
Optimizing Sub-cellular Localization Tags
The Seeker is looking for methods to optimize sub-cellular localization tags for protein expression....
-
Novel Approaches to Protecting Maize from Insect Damage
The Seeker is looking for novel approaches to protecting maize from insect damage. This Challenge re...
- More Challenges
- Powered by:
nature jobs
Professor
- University of Cincinnati and Cincinnati Children's Research Foundation
- Cincinnati, OH
Academic Neuropathologist
- University Hospitals Case Medical Center
- Cleveland, Ohio, USA
Molecular medicine: MicroRNAs and the tell-tale heart
Kenneth R. Chien1
Abstract
MicroRNAs are natural, single-stranded, small RNA molecules thought to control gene expression. Four studies indicate that specific microRNA sequences can regulate heart function in development and disease.
Understanding how complex physiological processes are coordinately controlled at the molecular level in vivo is one of the cornerstones of research in modern translational (bench-to-bedside) medicine. Using the heart as a model physiological system, four research teams1, 2, 3, 4 now establish a role for microRNAs (miRNAs or miRs) in the regulation of in vivo cardiac function: specifically, the conductance of electrical signals, heart muscle contraction, and heart growth and morphogenesis.
- Kenneth R. Chien is in the MGH Cardiovascular Research Center, Department of Cell Biology, Harvard Medical School and the Harvard Stem Cell Institute, Boston, Massachusetts 02114, USA.
Email: kchien@partners.org
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
MicroRNA may have macro effect on sudden deathNature Medicine News and Views (01 Apr 2007)
MicroRNA may have macro effect on sudden deathNature Medicine News and Views (01 Apr 2007)
RESEARCH
The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2Nature Medicine Letter (01 Apr 2007)
The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2Nature Medicine Letter (01 Apr 2007)
