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Nature 447, 271-272 (17 May 2007) | doi:10.1038/nature05888; Published online 7 May 2007
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Neuroscience: Wrestling with SUMO
Françoise Coussen1 & Daniel Choquet1
Abstract
The process of SUMOylation affects various cellular events by modifying the proteins involved. In neurons, it controls receptor numbers on the cell surface, thereby regulating neuronal communication.
With the identification of cellular mechanisms that control the efficiency of the dialogue between neurons, efforts to understand how the brain adapts to new stimuli have concentrated on molecular aspects of neuronal function. For example, the internalization and intracellular trafficking of receptors for neurotransmitters — chemicals that mediate communication between neurons — has emerged as a way of regulating receptor numbers on the neuronal surface and at synapses, the junctions between neurons.
- Françoise Coussen and Daniel Choquet are at the Institut François Magendie, Physiologie Cellulaire de la Synapse, UMR CNRS 5091, Université de Bordeaux, Bordeaux 33077, France.
Email: fcoussen@u-bordeaux2.fr
Email: dchoquet@u-bordeaux2.fr
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RESEARCH
SUMOylation regulates kainate-receptor-mediated synaptic transmissionNature Letters to Editor (17 May 2007)
PKC-dependent autoregulation of membrane kainate receptorsThe EMBO Journal Article (17 Oct 2007)
Activity-dependent endocytic sorting of kainate receptors to recycling or degradation pathwaysThe EMBO Journal Article (08 Dec 2004)
