Table of contents
Volume 447 Number 7141 pp115-230
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Editorials
A clear direction p115
The process established by the Intergovernmental Panel on Climate Change has generated a sound foundation of knowledge on which policy-makers must now build.
doi:10.1038/447115a
Starting at the top p115
Scientific élites retain a severe gender imbalance.
doi:10.1038/447115b
Under the microscope p116
The use of 'black box' techniques carries risks.
doi:10.1038/447116a
News
Climate panel offers grounds for optimism p120
The cost of fighting global warming may not be as high as feared.
Michael Hopkin
doi:10.1038/447120a
See also: Editor's summary
A clash of cosmologies p122
Is too much physics bad for astronomy?
Geoff Brumfiel
doi:10.1038/447122a
Snapshot: Ghosts of destruction p123
Satellite images reveal shrimp trawlers' turbulent trails.
doi:10.1038/447123a
Seven-year grant offers immune tolerance a boost p125
NIH gives initiative $220 million.
Erika Check
doi:10.1038/447125a
Sidelines p125
doi:10.1038/447125b
Wind farms' deadly reputation hard to shift p126
Cats far more lethal than turbines.
Emma Marris & Daemon Fairless
doi:10.1038/447126a
Microbe meeting promotes habitat conservation p127
Microorganisms deemed less important than their environment.
Helen Pearson
doi:10.1038/447127a
Column
Party of OneMisspent energy p130
US politicians are pushing to create an advanced research agency to tackle the energy challenges the nation faces. David Goldston explores why the current proposition may be ill-prepared for the task.
David Goldston
doi:10.1038/447130a
Business
Cheap at any price? p131
As AstraZeneca shells out $15 billion for a mid-sized US biotech firm, Heidi Ledford reports on the startling cost of staying in the drugs business.
doi:10.1038/447131a
News Features
Climate change: Is this what it takes to save the world? p132
Long marginalized as a dubious idea, altering the climate through 'geoengineering' has staged something of a comeback. Oliver Morton reports.
doi:10.1038/447132a
See also: Editor's summary
The good, the bad and the ugly p138
Imaging fluorescent molecules in live cells is revolutionizing cell biology. But a pretty image is not necessarily a good one, and many biologists are learning this the hard way, finds Helen Pearson.
doi:10.1038/447138a
See also: Editor's summary
Chemistry: Teetering on the edge p141
Why do chemists make compounds that could blow up in their faces? Emma Marris finds out... from a safe distance.
doi:10.1038/447141a
Correspondence
Structured digital abstract makes text mining easy p142
Mark Gerstein, Michael Seringhaus & Stanley Fields
doi:10.1038/447142a
Human reference sequence makes sense of names p142
Douglas L. Crawford
doi:10.1038/447142b
Codes must be updated so that names are known to all p142
Quentin D. Wheeler & Frank T. Krell
doi:10.1038/447142c
Commentary
A handful of carbon p143
Locking carbon up in soil makes more sense than storing it in plants and trees that eventually decompose, argues Johannes Lehmann. Can this idea work on a large scale?
doi:10.1038/447143a
See also: Editor's summary
Books and Arts
Plugged into the matrix p145
The rise and potential fall of the US electricity grid.
Paul M. Grant reviews The Grid: A Journey Through the Heart of Our Electrified World by Phillip F. Schewe
doi:10.1038/447145a
The stem-cell story p146
Justine Burley reviews Stem Cell Now: A Brief Introduction to the Coming Medical Revolution by Christopher Thomas Scott and Cell of Cells: The Global Race to Capture and Control the Stem Cell by Cynthia Fox and Stem Cell Wars: Inside Stories from the Frontlines by Eve Herold
doi:10.1038/447146a
Flight of the dinosaur p147
Angela Milner reviews Glorified Dinosaurs: The Origin and Early Evolution of Birds by Luis Chiappe
doi:10.1038/447147a
See also: Editor's summary
Science in culture: Hidden talent p148
An exhibition in London explores the art of blending into the background.
David M. Wilkinson
doi:10.1038/447148a
Essay
ConnectionsKinds of minds p149
Do differences in history, culture and education influence whether scientists focus on pieces and particulars, or make broad connections?
David Knight
doi:10.1038/447149a
News and Views
Behavioural neuroscience: Down memory lane p151
In mice, two treatments — environmental enrichment and a chemical that regulates gene expression — boost new memory formation and restore the recall of old memories that seemed to have been lost.
J. David Sweatt
doi:10.1038/nature05716
See also: Editor's summary
Organic chemistry: Radical catalysis p152
The domination of metals in catalysis is under threat as organic catalysts gain ground. The latest example may expand chemical reactivity beyond the achievements of traditional metal complexes.
Santanu Mukherjee & Benjamin List
doi:10.1038/447152a
Developmental biology: A chordate with a difference p153
Molecular studies of tunicate development show that genetic programmes for early embryonic patterning can change radically during evolution, without completely disrupting the basic chordate body plan.
Linda Z. Holland
doi:10.1038/447153a
50 & 100 Years Ago p154
doi:10.1038/447154a
Extrasolar planets: Remote climes p155
A distant planet traversing its orbit shows variations in its infrared brightness, providing the first map of its climate. These variations paint a picture of a dynamic world, with efficient redistribution of stellar heat.
Adam Burrows
doi:10.1038/447155a
See also: Editor's summary
Biochemistry: The big catch p156
The availability of short interfering RNAs (siRNAs) to silence gene expression has revolutionized research in molecular cell biology. But these synthetic siRNAs rely on cellular enzymes for their activity.
Christopher R. Trotta
doi:10.1038/447156a
Condensed-matter physics: Let's twist again p157
The spins of a layer of manganese atoms on a tungsten surface form a spiral pattern with a unique turning sense. Such 'chiral magnetic order' might exist in other, similar contexts, and could have many useful applications.
Christian Pfleiderer
&
Ulrich K. Rö
ler
doi:10.1038/447157a
See also: Editor's summary
Visual perception: A gloss on surface properties p158
Humans perceive the properties of a surface by interpreting visual input. When estimating gloss and lightness, it seems that neural discrimination of simple image statistics plays a large part.
Michael S. Landy
doi:10.1038/nature05714
See also: Editor's summary
Obituary: Ransom Aldrich Myers (1952–2007) p160
Chronicler of declining fish populations.
Daniel Pauly
doi:10.1038/447160a
Feature
Completing the map of human genetic variation p161
A plan to identify and integrate normal structural variation into the human genome sequence.
The Human Genome Structural Variation Working Group
doi:10.1038/447161a
See also: Editor's summary
Articles
Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences p167
Tarjei S. Mikkelsen, Matthew J. Wakefield, Bronwen Aken, Chris T. Amemiya, Jean L. Chang, Shannon Duke, Manuel Garber, Andrew J. Gentles, Leo Goodstadt, Andreas Heger, Jerzy Jurka, Michael Kamal, Evan Mauceli, Stephen M. J. Searle, Ted Sharpe, Michelle L. Baker, Mark A. Batzer, Panayiotis V. Benos, Katherine Belov, Michele Clamp, April Cook, James Cuff, Radhika Das, Lance Davidow, Janine E. Deakin, Melissa J. Fazzari, Jacob L. Glass, Manfred Grabherr, John M. Greally, Wanjun Gu, Timothy A. Hore, Gavin A. Huttley, Michael Kleber, Randy L. Jirtle, Edda Koina, Jeannie T. Lee, Shaun Mahony, Marco A. Marra, Robert D. Miller, Robert D. Nicholls, Mayumi Oda, Anthony T. Papenfuss, Zuly E. Parra, David D. Pollock, David A. Ray, Jacqueline E. Schein, Terence P. Speed, Katherine Thompson, John L. VandeBerg, Claire M. Wade, Jerilyn A. Walker, Paul D. Waters, Caleb Webber, Jennifer R. Weidman, Xiaohui Xie, Michael C. ZodyBroad Institute Genome Sequencing Platform and Broad Institute Whole Genome Assembly Team and , Jennifer A. Marshall Graves, Chris P. Ponting, Matthew Breen, Paul B. Samollow, Eric S. Lander & Kerstin Lindblad-Toh
doi:10.1038/nature05805
Abstract | Full Text | PDF (485K) | Supplementary information
See also: Editor's summary
Recovery of learning and memory is associated with chromatin remodelling p178
Andre Fischer, Farahnaz Sananbenesi, Xinyu Wang, Matthew Dobbin & Li-Huei Tsai
doi:10.1038/nature05772
Abstract | Full Text | PDF (1,569K) | Supplementary information
See also: Editor's summary | News and Views by Sweatt
Letters
A map of the day–night contrast of the extrasolar planet HD 189733b p183
Heather A. Knutson, David Charbonneau, Lori E. Allen, Jonathan J. Fortney, Eric Agol, Nicolas B. Cowan, Adam P. Showman, Curtis S. Cooper & S. Thomas Megeath
doi:10.1038/nature05782
First paragraph | Full Text | PDF (393K)
See also: Editor's summary | News and Views by Burrows
Superconductivity in lithium below 0.4 millikelvin at ambient pressure p187
Juha Tuoriniemi, Kirsi Juntunen-Nurmilaukas, Johanna Uusvuori, Elias Pentti, Anssi Salmela & Alexander Sebedash
doi:10.1038/nature05820
First paragraph | Full Text | PDF (295K)
See also: Editor's summary
Chiral magnetic order at surfaces driven by inversion asymmetry p190
M. Bode, M. Heide, K. von Bergmann, P. Ferriani, S. Heinze, G. Bihlmayer, A. Kubetzka, O. Pietzsch, S. Blügel & R. Wiesendanger
doi:10.1038/nature05802
First paragraph | Full Text | PDF (1,200K)
See also: Editor's summary | News and Views by Pfleiderer & Röler
Short-circuiting of the overturning circulation in the Antarctic Circumpolar Current p194
Alberto C. Naveira Garabato, David P. Stevens, Andrew J. Watson & Wolfgang Roether
doi:10.1038/nature05832
First paragraph | Full Text | PDF (578K) | Supplementary information
See also: Editor's summary
The depth distribution of azimuthal anisotropy in the continental upper mantle p198
Federica Marone & Barbara Romanowicz
doi:10.1038/nature05742
First paragraph | Full Text | PDF (683K) | Supplementary information
Sexual dimorphism and adaptive radiation in Anolis lizards p202
Marguerite A. Butler, Stanley A. Sawyer & Jonathan B. Losos
doi:10.1038/nature05774
First paragraph | Full Text | PDF (318K) | Supplementary information
See also: Editor's summary
Image statistics and the perception of surface qualities p206
Isamu Motoyoshi, Shin'ya Nishida, Lavanya Sharan & Edward H. Adelson
doi:10.1038/nature05724
First paragraph | Full Text | PDF (1,022K) | Supplementary information
See also: Editor's summary | News and Views by Landy
Maintaining a behaviour polymorphism by frequency-dependent selection on a single gene p210
Mark J. Fitzpatrick, Elah Feder, Locke Rowe & Marla B. Sokolowski
doi:10.1038/nature05764
First paragraph | Full Text | PDF (262K) | Supplementary information
See also: Editor's summary
A chromatin link that couples cell division to root epidermis patterning in Arabidopsis p213
Elena Caro, M. Mar Castellano & Crisanto Gutierrez
doi:10.1038/nature05763
First paragraph | Full Text | PDF (741K) | Supplementary information
The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex p218
Travis H. Stracker, Monica Morales, Suzana S. Couto, Hussein Hussein & John H. J. Petrini
doi:10.1038/nature05740
First paragraph | Full Text | PDF (568K) | Supplementary information
The human RNA kinase hClp1 is active on 3' transfer RNA exons and short interfering RNAs p222
Stefan Weitzer & Javier Martinez
doi:10.1038/nature05777
First paragraph | Full Text | PDF (522K) | Supplementary information
See also: News and Views by Trotta
Naturejobs
ProspectWriting has a crucial role in many different scientific pursuits p227
Paul Smaglik
doi:10.1038/nj7141-227a
Career Views
Pier Paolo Pandolfi, Director, Cancer Genetics Programme, Beth Israel Deaconess Medical Center, Harvard University p228
Cancer geneticist leaves Sloan Kettering for Harvard
Virginia Gewin
doi:10.1038/nj7141-228a
Earth network p228
Young scientists come together to tackle the complexities of climate change
Marko Scholze
doi:10.1038/nj7141-228b
Worst and best of times p228
Starting a completely new project has been just as daunting as I'd expected
Chris Rowan
doi:10.1038/nj7141-228c
Recruiters
The evolution of life-sciences sales p230
In the age of e-commerce, sales reps must give more than just information: they must be trusted advisers.
Tamara Zemlo
doi:10.1038/nj7141-230a