Access
To read this story in full you will need to login or make a payment (see right).
Insight
Nature 446, 1023-1029 (26 April 2007) | doi:10.1038/nature05816; Published online 25 April 2007
Open Innovation Challenges
- More Challenges
- Powered by:
nature jobs
Postdoctoral Position
- Fox Chase Cancer Center
- Philadelphia, Pennsylvania, United States, 19111
Business Devlopment Officer
- Rhydburg Pharmaceuticals
- Selaqui-Dehradun India
Glycan-based interactions involving vertebrate sialic-acid-recognizing proteins
Ajit Varki1
Abstract
All cells in nature are covered by a dense and complex array of carbohydrates. Given their prominence on cell surfaces, it is not surprising that these glycans mediate and/or modulate many cellular interactions. Proteins that bind sialic acid, a sugar that is found on the surface of the cell and on secreted proteins in vertebrates, are involved in a broad range of biological processes, including intercellular adhesion, signalling and microbial attachment. Studying the roles of such proteins in vertebrates has improved our understanding of normal physiology, disease and human evolution.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Unmasking connections in transmembrane immune signalingNature Immunology News and Views (01 Oct 2004)
Rolling on N-linked glycans: a new way to present L-selectin binding sitesNature Immunology News and Views (01 Apr 2007)
A sulfated address for lymphocyte homingNature Immunology News and Views (01 Nov 2005)
Glycan terminatorNature Structural & Molecular Biology News and Views (01 Nov 2009)
See all 10 matches for News And Views