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Nature 446, 1038-1045 (26 April 2007) | doi:10.1038/nature05818; Published online 25 April 2007

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Exploiting the defensive sugars of HIV-1 for drug and vaccine design

Christopher N. Scanlan1, John Offer2, Nicole Zitzmann1 & Raymond A. Dwek1

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The sustained effort towards developing an antibody vaccine against HIV/AIDS has provided much of our understanding of viral immunology. It is generally accepted that one of the main barriers to antibody neutralization of HIV is the array of protective structural carbohydrates that covers the antigens on the virus's surface. Intriguingly, however, recent findings suggest that these carbohydrates, which have evolved to protect HIV and promote its transmission, are also attractive therapeutic targets.

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