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Nature 446, 1008-1016 (26 April 2007) | doi:10.1038/nature05814; Published online 25 April 2007
Unusual sugar biosynthesis and natural product glycodiversification
Christopher J. Thibodeaux1, Charles E. Melançon2 & Hung-wen Liu1,2,3
Abstract
The enzymes involved in the biosynthesis of carbohydrates and the attachment of sugar units to biological acceptor molecules catalyse an array of chemical transformations and coupling reactions. In prokaryotes, both common sugar precursors and their enzymatically modified derivatives often become substituents of biologically active natural products through the action of glycosyltransferases. Recently, researchers have begun to harness the power of these biological catalysts to alter the sugar structures and glycosylation patterns of natural products both in vivo and in vitro. Biochemical and structural studies of sugar biosynthetic enzymes and glycosyltransferases, coupled with advances in bioengineering methodology, have ushered in a new era of drug development.
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