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Nature 446, 1000-1007 (26 April 2007) | doi:10.1038/nature05813; Published online 25 April 2007
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Assistant Professor and Associate Professor
- Massachusetts General Hospital/ Harvard Medical School
- Charlestown, MA
Gastroenterologist
- Wayne State University
- Detroit, Michigan, USA
Chemical glycosylation in the synthesis of glycoconjugate antitumour vaccines
Danica P. Galoni
1
&
David Y. Gin2
Abstract
Therapeutic vaccines derived from carbohydrate antigen–adjuvant combinations are a promising approach for cancer immunotherapy. One of the critical limitations in this area is access to sufficient quantities of tumour-associated carbohydrate antigens and glycoconjugate adjuvants. At present, availability of the complex oligosaccharide constructs that are needed for the systematic design and evaluation of novel vaccine formulations relies on de novo chemical synthesis. The use of both state-of-the-art and emerging glycosylation technologies has led to significant advances in this field, allowing the clinical exploration of carbohydrate-based antigens in the treatment of cancer.
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