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Nature 446, 996-997 (26 April 2007) | doi:10.1038/446996a; Published online 25 April 2007
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Research Fellows in Pluripotent Stem Cell Technology
- The University of Nottingham
- Nottingham, UK
Laboratory Manager / Principal Research Assistant
- Wellcome Trust Sanger Institute
- Hinxton, Cambridge, CB10 1SA, UK
Stem cells: Blood lines from embryo to adult
Hiroo Ueno1 & Irving L. Weissman1
Abstract
Does blood formation in mammalian embryos and adults have separate origins or a common source? The most recent investigations into the question add a further chapter to this long-running story.
Thirty years ago the consensus view was that blood formation — haematopoiesis — originates in stem cells in the embryo yolk sac, with that same cell lineage going on to supply the fetus and adult. This was supplanted by the now-conventional wisdom that the yolk sac serves only the embryo, and that an independent origin of blood-forming stem cells begins in the region of the developing fetus known as the aorta–gonad–mesonephros (AGM).
- Hiroo Ueno and Irving L. Weissman are at the Institute of Stem Cell Biology and Regenerative Medicine, Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA.
Email: hueno@stanford.edu
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