Table of contents
Volume 446 Number 7138 pp831-948
(this content only available online) indicates content that is available online only
Editorials
Plus ça change? p831
The winner of France's election will find scientists willing to support the right kind of reforms.
doi:10.1038/446831a
Small steps forward p832
The presidency of Olusegun Obasanjo, whatever its pitfalls, has been positive for Nigerian science.
doi:10.1038/446832a
Addicted to secrecy p832
Sealed drug documents should be opened up.
doi:10.1038/446832b
News
Colliders race for the Higgs p836
Setbacks at CERN offer Tevatron a chance to snatch the prize.
Sarah Tomlin
doi:10.1038/446836a
Interim view from NASA relativity probe p837
Results close in on Einstein's prediction.
Sarah Tomlin
doi:10.1038/446837a
Evidence for fourth neutrino fades p837
Fermilab detector quashes sterile particle.
Jenny Hogan
doi:10.1038/446837b
Court case to reclaim confidential data p838
Prosecution highlights how drug data can be removed from public view.
Jim Giles
doi:10.1038/446838a
Ozone sensor to be reinstated p839
Axed US instrument will fly at last.
Emma Marris
doi:10.1038/446839a
Make way for monkeys p840
Macaque genome sequence provides sideways look at human disease.
Erika Check
doi:10.1038/446840a
Chimps lead evolutionary race p841
More chimpanzee genes have been positively selected for than human ones.
Michael Hopkin
doi:10.1038/446841a
Sidelines p841
doi:10.1038/446841b
Stem-cell issue moves up the US agenda p842
Senate vote aims to promote debate.
Meredith Wadman
doi:10.1038/446842a
Business
Moment of reckoning p844
Fresh laws on the regulation of medicines are working their way through the US Congress — but will they strike the right balance between public safety and innovation? Meredith Wadman investigates.
doi:10.1038/446844a
See also: Editor's summary
In brief p845
doi:10.1038/446845a
Market watch p845
Colin Macilwain
doi:10.1038/446845b
News Features
French election: The candidates respond p847
France's presidential elections are taking place at a time of deep debate over the French research community's standing and prospects. To further the debate, Nature's Declan Butler submitted a list of questions on research issues to the three leading candidates. Their full responses, in both French and English, are on our website. Here we present extracts:
doi:10.1038/446847a
Full Text | PDF (694K) | Supplementary information
See also: Editor's summary
French election: Let science speak for itself p850
You've heard what the presidential candidates think the challenges facing science in France are. Nature also canvassed opinion across the French research spectrum: from young researchers to reformers and industrialists. Declan Butler reports.
doi:10.1038/446850a
French election: Is French science in decline... p854
...or have its failings been greatly exaggerated? Declan Butler finds out.
doi:10.1038/446854a
Correspondence
Other riffs on cooperation are already showing how well a wiki could work p856
John D. Osborne, Simon Lin & Warren A. Kibbe
doi:10.1038/446856a
Law and research could add up to profitable niche drugs p856
Burkhard Haefner
doi:10.1038/446856b
Why do so few women speak at science meetings? p856
Pamela A. Silver
doi:10.1038/446856c
Who will start the 3Rs ball rolling for animal welfare? p856
Victoria Buck
doi:10.1038/446856d
Books and Arts
Relative confusion p857
The implications of Einstein's special and general theories of relativity were not immediately apparent.
William Unruh reviews The Curious History of Relativity: How Einstein's Theory of Gravity was Lost and Found Again by Jean Eisenstaedt
doi:10.1038/446857a
A hunger for company p858
Gary Paul Nabhan reviews Feast: Why Humans Share Food by Martin Jones
doi:10.1038/446858a
See also: Editor's summary
Play: Here's looking at you p859
Serendib by David Zellnik
Alan Packer
doi:10.1038/446859a
No firm promises p859
Keith Redpath reviews Science Business: The Promise, the Reality, and the Future of Biotech by Gary P. Pisano
doi:10.1038/446859b
Essay
ConnectionsRules of engagement p860
Complex engineered and biological systems share protocol-based architectures that make them robust and evolvable, but with hidden fragilities to rare perturbations.
John Doyle & Marie Csete
doi:10.1038/446860a
See also: Editor's summary
News and Views
Palaeobotany: A tree without leaves p861
The puzzle presented by the famous stumps of Gilboa, New York, finds a solution in the discovery of two fossil specimens that allow the entire structure of these early trees to be reconstructed.
Brigitte Meyer-Berthaud & Anne-Laure Decombeix
doi:10.1038/446861a
See also: Editor's summary
50 & 100 Years Ago p862
doi:10.1038/446862a
Earth science: When crust is bred p863
An analysis of the distribution of helium-isotope ratios in oceanic extrusions from Earth's mantle seems to establish a connection with the spread of ages in continental crust. What mechanism might underlie this?
Don Porcelli
doi:10.1038/446863a
See also: Editor's summary
RNA silencing: Genomic defence with a slice of pi p864
In fruit flies, a few very large genes generate the small RNAs that silence parasitic DNA elements. These RNAs might also participate in an amplification circuit that increases their potency.
Phillip D. Zamore
doi:10.1038/446864a
See also: Editor's summary
Neurobiology: Feeling right about doing right p865
Reason and emotion come into conflict in making all kinds of judgements. Results of work with brain-damaged patients constitute one line of evidence that the emotional component is not to be dismissed.
Deborah Talmi & Chris Frith
doi:10.1038/446865a
See also: Editor's summary
Quantum mechanics: To be or not to be local p866
The experimental violation of mathematical relations known as Bell's inequalities sounded the death-knell of Einstein's idea of 'local realism' in quantum mechanics. But which concept, locality or realism, is the problem?
Alain Aspect
doi:10.1038/446866a
See also: Editor's summary
Cell biology: The checkpoint brake relieved p868
When a cell divides, each daughter cell inherits a complete set of chromosomes. A sophisticated inhibitory mechanism delays chromosome segregation and cell division until everything is in its place.
Jan-Michael Peters
doi:10.1038/446868a
Social science: The urban organism p869
Richard Webb
doi:10.1038/446869a
Correction p869
doi:10.1038/446869b
Obituary: Donald E. Osterbrock (1924–2007) p870
Astrophysicist and historian of astronomy.
Joseph S. Miller
doi:10.1038/446870a
Articles
An experimental test of non-local realism p871
Simon Gröblacher,
Tomasz Paterek,
Rainer Kaltenbaek,
aslav Brukner,
Marek 
ukowski,
Markus Aspelmeyer
&
Anton Zeilinger
doi:10.1038/nature05677
Abstract | Full Text | PDF (307K) | Supplementary information
See also: Editor's summary | News and Views by Aspect
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities p876
Frank Stegmeier, Michael Rape, Viji M. Draviam, Grzegorz Nalepa, Mathew E. Sowa, Xiaolu L. Ang, E. Robert McDonald III, Mamie Z. Li, Gregory J. Hannon, Peter K. Sorger, Marc W. Kirschner, J. Wade Harper & Stephen J. Elledge
doi:10.1038/nature05694
Abstract | Full Text | PDF (1,170K) | Supplementary information
See also: Editor's summary | News and Views by Peters
Opposing LSD1 complexes function in developmental gene activation and repression programmes p882
Jianxun Wang, Kathleen Scully, Xiaoyan Zhu, Ling Cai, Jie Zhang, Gratien G. Prefontaine, Anna Krones, Kenneth A. Ohgi, Ping Zhu, Ivan Garcia-Bassets, Forrest Liu, Havilah Taylor, Jean Lozach, Friederike L. Jayes, Kenneth S. Korach, Christopher K. Glass, Xiang-Dong Fu & Michael G. Rosenfeld
doi:10.1038/nature05671
Abstract | Full Text | PDF (1,339K) | Supplementary information
Letters
Iron meteorite evidence for early formation and catastrophic disruption of protoplanets p888
Jijin Yang, Joseph I. Goldstein & Edward R. D. Scott
doi:10.1038/nature05735
First paragraph | Full Text | PDF (297K) | Supplementary information
See also: Editor's summary
A quantum scattering interferometer p892
Russell A. Hart, Xinye Xu, Ronald Legere & Kurt Gibble
doi:10.1038/nature05680
First paragraph | Full Text | PDF (324K)
See also: Editor's summary
Regioselective one-pot protection of carbohydrates p896
Cheng-Chung Wang, Jinq-Chyi Lee, Shun-Yuan Luo, Suvarn S. Kulkarni, Yu-Wen Huang, Chia-Chen Lee, Ken-Lien Chang & Shang-Cheng Hung
doi:10.1038/nature05730
First paragraph | Full Text | PDF (267K) | Supplementary information
See also: Editor's summary
Helium isotopic evidence for episodic mantle melting and crustal growth p900
S. W. Parman
doi:10.1038/nature05691
First paragraph | Full Text | PDF (369K) | Supplementary information
See also: Editor's summary | News and Views by Porcelli
Giant cladoxylopsid trees resolve the enigma of the Earth's earliest forest stumps at Gilboa p904
William E. Stein, Frank Mannolini, Linda VanAller Hernick, Ed Landing & Christopher M. Berry
doi:10.1038/nature05705
First paragraph | Full Text | PDF (1,742K) | Supplementary information
See also: Editor's summary | News and Views by Meyer-Berthaud & Decombeix
Damage to the prefrontal cortex increases utilitarian moral judgements p908
Michael Koenigs, Liane Young, Ralph Adolphs, Daniel Tranel, Fiery Cushman, Marc Hauser & Antonio Damasio
doi:10.1038/nature05631
First paragraph | Full Text | PDF (477K) | Supplementary information
See also: Editor's summary | News and Views by Talmi & Frith
A new perceptual illusion reveals mechanisms of sensory decoding p912
Mehrdad Jazayeri & J. Anthony Movshon
doi:10.1038/nature05739
First paragraph | Full Text | PDF (392K) | Supplementary information
See also: Editor's summary
TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity p916
Michaela U. Gack, Young C. Shin, Chul-Hyun Joo, Tomohiko Urano, Chengyu Liang, Lijun Sun, Osamu Takeuchi, Shizuo Akira, Zhijian Chen, Satoshi Inoue & Jae U. Jung
doi:10.1038/nature05732
First paragraph | Full Text | PDF (1,576K) | Supplementary information
Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation p921
S. K. Reddy, M. Rape, W. A. Margansky & M. W. Kirschner
doi:10.1038/nature05734
First paragraph | Full Text | PDF (652K) | Supplementary information
See also: Editor's summary | News and Views by Peters
Unproductive splicing of SR genes associated with highly conserved and ultraconserved DNA elements p926
Liana F. Lareau, Maki Inada, Richard E. Green, Jordan C. Wengrod & Steven E. Brenner
doi:10.1038/nature05676
First paragraph | Full Text | PDF (1,272K) | Supplementary information
A stepwise mechanism for acetylcholine receptor channel gating p930
Prasad Purohit, Ananya Mitra & Anthony Auerbach
doi:10.1038/nature05721
First paragraph | Full Text | PDF (380K) | Supplementary information
Corrigendum
Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages p934
K.-L. Laugwitz, A. Moretti, J. Lam, P. Gruber, Y. Chen, S. Woodard, L.-Z. Lin, C.-L. Cai, M. M. Lu, M. Reth, O. Platoshyn, J. X.-J. Yuan, S. Evans & K. R. Chien
doi:10.1038/nature05790
Technology Features
Cell biology: Close-up on cell biology p937
To define the workings of cellular structures and molecules requires cutting-edge technology not only in biology and biochemistry, but also now in nanotechnology. Hayley M. Birch and Julie Clayton report.
Hayley M. Birch & Julie Clayton
doi:10.1038/446937a
Cell biology: Cell culture in three dimensions p937
doi:10.1038/446937b
Cell biology: Down to the letter p940
doi:10.1038/446940a
See also: Editor's summary
Cell biology: Table of suppliers p941
doi:10.1038/446941a
Naturejobs
ProspectProspect p943
Scientific couples face different kinds of distance for both romantic and career success.
Paul Smaglik
doi:10.1038/nj7138-943a
Postdocs and Students
The places in between p944
Taking time between university and graduate school to gain more research experience is time well spent. Kendall Powell uncovers a growing trend for US students.
Kendall Powell
doi:10.1038/nj7138-944a
Career Views
Thomas Hudson, president and scientific director, Ontario Institute for Cancer Research, Toronto, Canada p946
Genome expert takes on new project.
Hannah Hoag
doi:10.1038/nj7138-946a
A more attractive career p946
Eurodoc seeks better conditions for graduate students.
Koen van Dam
doi:10.1038/nj7138-946b
Science for life? p946
Should I feel ashamed that my research is sometimes just a job rather than a calling?
Peter Jordan
doi:10.1038/nj7138-946c
Recruiters
The inside track from academia and industry: (And they call it) guppy love p948
A Singapore agency has been recruiting and raising young scientists to swim with the 'whales'.
Philip Yeo
doi:10.1038/nj7138-948a
Highlights
Highlight: Francophone
doi:10.1038/nj0155
Opportunities: The National Institutes of Health
doi:10.1038/nj0156