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News and Views
Nature 446, 864-865 (19 April 2007) | doi:10.1038/446864a; Published online 18 April 2007
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RNA silencing: Genomic defence with a slice of pi
Phillip D. Zamore1
Abstract
In fruit flies, a few very large genes generate the small RNAs that silence parasitic DNA elements. These RNAs might also participate in an amplification circuit that increases their potency.
Nearly half of the human genome and a third of the fruit fly's consists of selfish elements called transposons, 'jumping genes' that insert themselves into new locations, mutating other genes and damaging chromosomes. These molecular parasites include simple nucleotide repeats and virus-like elements that have colonized genomes throughout evolution.
- Phillip D. Zamore is in the Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Email: phillip.zamore@umassmed.edu
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