Editorials

Climate change, here and now p701

Poor nations need the data that show what is already happening to their climate, as well as the resources with which to adapt to change.

doi:10.1038/446701a

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Science without borders p701

Researchers should push for rule changes to make Europe work as one.

doi:10.1038/446701b

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When employees attack p702

Government scientists should be able to comment publicly — within reason.

doi:10.1038/446702a

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Research Highlights

Research highlights p704

doi:10.1038/446704a

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News

Climate takes aim p706

Attention is now turning to the developing world, where those least equipped to handle it will bear the brunt of global warming. Michael Hopkin reports.

Michael Hopkin

doi:10.1038/446706a

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Dinosaur prints lead to crediting row p708

Turf war overshadows discovery of sauropod tracks.

Rex Dalton

doi:10.1038/446708a

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Physicists question model of the Universe p709

The search continues for a non-standard theory.

Jenny Hogan

doi:10.1038/446709a

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Venezuelan free-speech row goes nuclear p711

Physicist is demoted after criticizing government officials.

Michael Hopkin

doi:10.1038/446711a

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News in brief p713

doi:10.1038/446713a

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Correction p713

doi:10.1038/446713b

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Column

Back to school p714

The US National Science Foundation may soon have to supply lab equipment to poverty-stricken high schools. David Goldston explains why some politicians want the agency to pay for Bunsen burners and test-tubes.

David Goldston

doi:10.1038/446714a

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Business

Plastic promises p715

Car companies know that plastic parts made from plants will appeal to 'green' customers. But as Ichiko Fuyuno reports, their progress has been painfully slow.

doi:10.1038/446715a

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News Features

Climate Change 2007: How to survive a warming world p716

African communities have been adapting to climate change for millennia. Jim Giles reports on the strategies that seem most effective.

doi:10.1038/446716a

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Climate Change 2007: A world melting from the top down p718

Despite years of speculation, little can be said for sure about the future of the Arctic's permafrost. But that's no grounds for complacency, reports Gabrielle Walker.

doi:10.1038/446718a

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Climate Change 2007: Al's Army p723

Members of the public are taking to the streets to spread Al Gore's message of climate crisis. Amanda Haag meets the foot soldiers of global warming.

doi:10.1038/446723a

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Correspondence

Save your notes, drafts and printouts: today's work is tomorrow's history p725

Sydney Brenner & Richard J. Roberts

doi:10.1038/446725a

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See also: Editor's summary

Reliance on bibliometric databases can let you down p725

Brian Haynes

doi:10.1038/446725b

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Increasing prose quality by decreasing word repetition p725

Cheryl Strauss

doi:10.1038/446725c

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Commentary

Climate change 2007: Spring-time for sinks p727

Carbon sinks play a key role in slowing the growth of carbon dioxide levels in the atmosphere. These sinks are at risk as the world warms, but their demise is not inevitable, say Dave Reay and his colleagues.

doi:10.1038/446727a

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Books and Arts

Industrial relations p729

What lessons can be learned from a landmark deal between a company and a university department?

Scott Wallsten reviews Universities in the Age of Corporate Science: The UC Berkeley-Novartis Controversy by Alan P. Rudy, Dawn Coppin, Jason Konefal, Bradley T. Shaw, Toby Ten Eyck, Craig Harris & Lawrence Busch

doi:10.1038/446729a

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Builders with little brains p730

Tore Slagsvold reviews Animal Architects: Building and the Evolution of Intelligence by James L. Gould & Carol Grant Gould

doi:10.1038/446730a

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The birth of science p731

Peter Dear reviews The Emergence of a Scientific Culture: Science and the Shaping of Modernity 1210–1685 by Stephen Gaukroger

doi:10.1038/446731a

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Science books award p731

doi:10.1038/446731b

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Essay

Capturing human behaviour p733

Understanding the dynamics of infectious-disease transmission demands a holistic approach, yet today's models largely ignore how epidemics change individual behaviour.

Neil Ferguson

doi:10.1038/446733a

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News and Views

Cancer: Division of labour p735

Some genes are involved in the development of a new tumour; others specifically promote the dissemination of its cancerous cells to other organs. A set of four genes seems to be required for both processes.

Gerhard Christofori

doi:10.1038/446735a

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Solid-state chemistry: Crystal tennis rackets p736

The idea of bendy crystals, especially ones that move rapidly and reversibly in response to light, seems strange. Such materials have now been prepared — but how do they change shape so dramatically without cracking?

J. Michael McBride

doi:10.1038/446736a

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50 & 100 Years Ago p737

doi:10.1038/446737a

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Genomics: Global views of leukaemia p739

Genomic characterization of a type of leukaemia has resulted in the identification of common genetic abnormalities that underlie the disease. The results constitute an advance on several fronts.

Todd R. Golub

doi:10.1038/446739a

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Geology: Crystal-clear ideas p739

Richard Webb

doi:10.1038/446739b

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Biophysics: Quantum path to photosynthesis p740

Knowing how plants and bacteria harvest light for photosynthesis so efficiently could provide a clean solution to mankind's energy requirements. The secret, it seems, may be the coherent application of quantum principles.

Roseanne J. Sension

doi:10.1038/446740a

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Cell biology: Fraternal twins p741

A popular route for protein transport into and across cell membranes is through the Sec channel. This channel seems to function by forming a dimer of two identical units, where each has a distinct role.

Franck Duong

doi:10.1038/446741a

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Ecology: Poole resources p743

Tim Lincoln

doi:10.1038/446743a

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Obituary: Knut Schmidt-Nielsen (1915–2007) p744

Quests in comparative physiology.

R. McNeill Alexander

doi:10.1038/446744a

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News and Views Q&A

Cell biology: Autophagy and cancer p745

Autophagy is the degradation of redundant or faulty cell components. It occurs as part of a cell's everyday activities and as a response to stressful stimuli, such as starvation. Connections with cellular life-and-death decisions and with cancer are now emerging.

Beth Levine

doi:10.1038/446745a

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Review

Multiple molecular mechanisms for multidrug resistance transporters p749

Christopher F. Higgins

doi:10.1038/nature05630

First paragraph | Full Text | PDF (1,309K)

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Articles

Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia p758

Charles G. Mullighan, Salil Goorha, Ina Radtke, Christopher B. Miller, Elaine Coustan-Smith, James D. Dalton, Kevin Girtman, Susan Mathew, Jing Ma, Stanley B. Pounds, Xiaoping Su, Ching-Hon Pui, Mary V. Relling, William E. Evans, Sheila A. Shurtleff & James R. Downing

doi:10.1038/nature05690

Abstract | Full Text | PDF (941K) | Supplementary information

See also: Editor's summary | News and Views by Golub

Mediators of vascular remodelling co-opted for sequential steps in lung metastasis p765

Gaorav P. Gupta, Don X. Nguyen, Anne C. Chiang, Paula D. Bos, Juliet Y. Kim, Cristina Nadal, Roger R. Gomis, Katia Manova-Todorova & Joan Massagué

doi:10.1038/nature05760

Abstract | Full Text | PDF (1,127K) | Supplementary information

See also: Editor's summary | News and Views by Christofori

Letters

A laboratory demonstration of the capability to image an Earth-like extrasolar planet p771

John T. Trauger & Wesley A. Traub

doi:10.1038/nature05729

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Optical coherent state discrimination using a closed-loop quantum measurement p774

Robert L. Cook, Paul J. Martin & J. M. Geremia

doi:10.1038/nature05655

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Rapid and reversible shape changes of molecular crystals on photoirradiation p778

Seiya Kobatake, Shizuka Takami, Hiroaki Muto, Tomoyuki Ishikawa & Masahiro Irie

doi:10.1038/nature05669

First paragraph | Full Text | PDF (607K) | Supplementary information

See also: Editor's summary | News and Views by McBride

Evidence for wavelike energy transfer through quantum coherence in photosynthetic systems p782

Gregory S. Engel, Tessa R. Calhoun, Elizabeth L. Read, Tae-Kyu Ahn, Tomá Manal, Yuan-Chung Cheng, Robert E. Blankenship & Graham R. Fleming

doi:10.1038/nature05678

First paragraph | Full Text | PDF (1,445K) | Supplementary information

See also: Editor's summary | News and Views by Sension

A periodic shear-heating mechanism for intermediate-depth earthquakes in the mantle p787

Peter B. Kelemen & Greg Hirth

doi:10.1038/nature05717

First paragraph | Full Text | PDF (2,003K) | Supplementary information

Grassland species loss resulting from reduced niche dimension p791

W. Stanley Harpole & David Tilman

doi:10.1038/nature05684

First paragraph | Full Text | PDF (399K) | Supplementary information

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Egalitarian motives in humans p794

Christopher T. Dawes, James H. Fowler, Tim Johnson, Richard McElreath & Oleg Smirnov

doi:10.1038/nature05651

First paragraph | Full Text | PDF (147K) | Supplementary information

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A mirror-symmetric cell division that orchestrates neuroepithelial morphogenesis p797

Marcel Tawk, Claudio Araya, Dave A. Lyons, Alexander M. Reugels, Gemma C. Girdler, Philippa R. Bayley, David R. Hyde, Masazumi Tada & Jonathan D. W. Clarke

doi:10.1038/nature05722

First paragraph | Full Text | PDF (1,557K) | Supplementary information

Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry p801

Matthew J. Evans, Thomas von Hahn, Donna M. Tscherne, Andrew J. Syder, Maryline Panis, Benno Wölk, Theodora Hatziioannou, Jane A. McKeating, Paul D. Bieniasz & Charles M. Rice

doi:10.1038/nature05654

First paragraph | Full Text | PDF (371K) | Supplementary information

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Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map p806

Sean R. Collins, Kyle M. Miller, Nancy L. Maas, Assen Roguev, Jeffrey Fillingham, Clement S. Chu, Maya Schuldiner, Marinella Gebbia, Judith Recht, Michael Shales, Huiming Ding, Hong Xu, Junhong Han, Kristin Ingvarsdottir, Benjamin Cheng, Brenda Andrews, Charles Boone, Shelley L. Berger, Phil Hieter, Zhiguo Zhang, Grant W. Brown, C. James Ingles, Andrew Emili, C. David Allis, David P. Toczyski, Jonathan S. Weissman, Jack F. Greenblatt & Nevan J. Krogan

doi:10.1038/nature05649

First paragraph | Full Text | PDF (1,774K) | Supplementary information

Conserved factors regulate signalling in Arabidopsisthaliana shoot and root stem cell organizers p811

Ananda K. Sarkar, Marijn Luijten, Shunsuke Miyashima, Michael Lenhard, Takashi Hashimoto, Keiji Nakajima, Ben Scheres, Renze Heidstra & Thomas Laux

doi:10.1038/nature05703

First paragraph | Full Text | PDF (1,348K) | Supplementary information

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Synthetic lethal screen identification of chemosensitizer loci in cancer cells p815

Angelique W. Whitehurst, Brian O. Bodemann, Jessica Cardenas, Deborah Ferguson, Luc Girard, Michael Peyton, John D. Minna, Carolyn Michnoff, Weihua Hao, Michael G. Roth, Xian-Jin Xie & Michael A. White

doi:10.1038/nature05697

First paragraph | Full Text | PDF (440K) | Supplementary information

Backtracking determines the force sensitivity of RNAP II in a factor-dependent manner p820

Eric A. Galburt, Stephan W. Grill, Anna Wiedmann, Lucyna Lubkowska, Jason Choy, Eva Nogales, Mikhail Kashlev & Carlos Bustamante

doi:10.1038/nature05701

First paragraph | Full Text | PDF (2,314K) | Supplementary information

Corrigendum

The Polycomb group protein EZH2 directly controls DNA methylation p824

Emmanuelle Viré, Carmen Brenner, Rachel Deplus, Loïc Blanchon, Mario Fraga, Céline Didelot, Lluis Morey, Aleyde Van Eynde, David Bernard, Jean-Marie Vanderwinden, Mathieu Bollen, Manel Esteller, Luciano Di Croce, Yvan de Launoit & François Fuks

doi:10.1038/nature05710

Full Text | PDF (67K) | Supplementary information

Addendum

Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor p824

Marcos H. Hatada, Xiaode Lu, Ellen R. Laird, Jeremy Green, Jay P. Morgenstern, Meizhen Lou, Chris S. Marr, Thomas B. Phillips, Mary K. Ram, Kelly Theriault, Mark J. Zoller & Jennifer L. Karas

doi:10.1038/nature05727

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Naturejobs

Young scientists flock to networking sites. p825

Paul Smaglik

doi:10.1038/nj7137-825a

Full Text | PDF (161K)

Genes versus cancer p826

Just a decade has changed cancer research beyond recognition, but adaptable skills and teamwork lead to exciting possibilities. Ricki Lewis looks at the new face of cancer genetics.

Ricki Lewis

doi:10.1038/nj7137-826a

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Stephen Cohen, director, Temasek Life Sciences Laboratory, Singapore p828

Canadian researcher switches continents yet again.

Ichiko Fuyuno

doi:10.1038/nj7137-828a

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Crossing boundaries p828

Fellow finds interdicisplinary options.

Giovanni Frazzetto

doi:10.1038/nj7137-828b

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Missing the mundane p828

Postdoc adapting to new minutae in South Africa.

Chris Rowan

doi:10.1038/nj7137-828c

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The inside track from academia and industry: Tough sell p830

Let's talk money: what you're likely to earn, how to get a pay rise and when to consider other options.

Martin Lang

doi:10.1038/nj7137-830a

Full Text | PDF (71K)