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News and Views
Nature 446, 741-743 (12 April 2007) | doi:10.1038/446741a; Published online 11 April 2007
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Assistant / Associate / Full Professor
- Northeastern University
- Boston, MA
Technical Manager
- University of Glasgow
- Glasgow, UK
Cell biology: Fraternal twins
Franck Duong1
Abstract
A popular route for protein transport into and across cell membranes is through the Sec channel. This channel seems to function by forming a dimer of two identical units, where each has a distinct role.
The transmembrane Sec channel, or Sec translocon, is a major protein-transport route across the endoplasmic reticulum of higher organisms and the cell membrane of bacteria. This essential machinery ensures the correct distribution of cellular proteins, and catalyses the translocation, and membrane integration, of hundreds of different proteins that carry a specific targeting signal called the signal sequence.
- Franck Duong is in the Department of Biochemistry and Molecular Biology, Life Sciences Institute, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Email: fduong@interchange.ubc.ca
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