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Nature 446, 735-736 (12 April 2007) | doi:10.1038/446735a; Published online 11 April 2007

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Cancer: Division of labour

Gerhard Christofori1

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Some genes are involved in the development of a new tumour; others specifically promote the dissemination of its cancerous cells to other organs. A set of four genes seems to be required for both processes.

Most deaths from cancer are due to metastasis, or the spread of cancer cells. The discovery of gene sets, or 'signatures', whose expression is associated with general and organ-specific metastasis has prompted the first screening programmes in the clinic1, 2.

  1. Gerhard Christofori is at the Institute of Biochemistry and Genetics, Department of Clinical–Biological Sciences (DKBW), University of Basel, Center for Biomedicine, Mattenstrasse 28, CH-4058 Basel, Switzerland.
    Email: gerhard.christofori@unibas.ch

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