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Nature 446, 735-736 (12 April 2007) | doi:10.1038/446735a; Published online 11 April 2007
Cancer: Division of labour
Gerhard Christofori1
Abstract
Some genes are involved in the development of a new tumour; others specifically promote the dissemination of its cancerous cells to other organs. A set of four genes seems to be required for both processes.
Most deaths from cancer are due to metastasis, or the spread of cancer cells. The discovery of gene sets, or 'signatures', whose expression is associated with general and organ-specific metastasis has prompted the first screening programmes in the clinic1, 2.
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