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From the following article:

Mediators of vascular remodelling co-opted for sequential steps in lung metastasis

Gaorav P. Gupta, Don X. Nguyen, Anne C. Chiang, Paula D. Bos, Juliet Y. Kim, Cristina Nadal, Roger R. Gomis, Katia Manova-Todorova & Joan Massagué

Nature 446, 765-770(12 April 2007)

doi:10.1038/nature05760

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

EREG, MMP1, MMP2 and COX2 cooperate to mediate primary tumour growth.

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Figure 2

EREG, MMP1, MMP2 and COX2 mediate tumour angiogenic progression.

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Figure 3

Genetic inhibition of EREG, MMP1, MMP2 and COX2 prevents metastatic extravasation.

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Figure 4

Pharmacological inhibition of tumour growth and dissemination in orthotopically implanted primary tumours.

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Figure 5

Targeted inhibition of metastatic extravasation and lung colonization by LM2 and primary malignant cells.

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