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From the following article:

Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin

Jun-Li Luo, Wei Tan, Jill M. Ricono, Olexandr Korchynskyi, Ming Zhang, Steven L. Gonias, David A. Cheresh & Michael Karin

Nature 446, 690-694(5 April 2007)

doi:10.1038/nature05656

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

IKKalpha activity is required for prostate cancer metastasis.

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Figure 2

Maspin expression correlates with metastatogenesis.

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Figure 3

Activated nuclear IKKalpha represses Maspin transcription.

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Figure 4

Metastatic progression correlates with nuclear activation of IKKalpha, inflammatory cell infiltration and massive upregulation of RANKL.

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