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Nature 446, 557-561 (14 March 2007) | doi:10.1038/nature05698;
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Epithelial NEMO links innate immunity to chronic intestinal inflammation
Deregulation of intestinal immune responses seems to have a principal function in the pathogenesis of inflammatory bowel disease. The gut epithelium is critically involved in the maintenance of intestinal immune homeostasis—acting as a physical barrier separating luminal bacteria and immune cells, and also expressing antimicrobial peptides.
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