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Nature 446, 485-486 (29 March 2007) | doi:10.1038/446485a; Published online 28 March 2007

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Stem cells: The hard copy

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Researchers have found certain stem-cell studies notoriously difficult to replicate. Erika Check finds out why, and whether it is slowing down the field.

Eight years ago, a team of scientists based in Canada and Italy published an astonishing paper in Science. They started with mouse neural stem cells — cells destined to give rise to brain tissue.