Table of contents

indicates content that is available online only


Top

Editorials

Safe in their hands? p469

Britain's restructuring of research funding and the budget announced last week are welcome. But a cloud still hangs over basic biomedical science.

doi:10.1038/446469a


Mutant mice galore p469

A new consortium will fulfil a genomics dream — provided it gets the support it deserves.

doi:10.1038/446469b


Cut the climate antics p470

A long run of congressional theatre should close.

doi:10.1038/446470a


Top

Research Highlights

Research highlights p472

doi:10.1038/446472a


Top

News

Cancer patients opt for unapproved drug p474

Internet trade pre-empts clinical trial.

Helen Pearson

doi:10.1038/446474a


Database targets Parsi genes p475

Biotech firm aims to collate health data for 69,000-strong community.

K. S. Jayaraman

doi:10.1038/446475a


Sidelines p476

doi:10.1038/446476a


Chinese network to start trials of spinal surgery p476

Surgeons agree on guidelines for stem-cell operations.

David Cyranoski

doi:10.1038/446476b


Snapshot p477

Hinode spacecraft changes our view of the Sun.

doi:10.1038/446477a


Darwin and the 20-year publication gap p478

Was On the Origin of Species really delayed by religious fears?

Lucy Odling-Smee

doi:10.1038/446478a


Q&A: A vision for Italy's role in space p478

Giovanni Bignami, incoming president of the Italian Space Agency, looks to the future.

doi:10.1038/446478b


Congress requests bubble-fusion reports p480

Spotlight falls on Purdue's inquiry.

Eugenie Samuel Reich

doi:10.1038/446480a


News in brief p481

doi:10.1038/446481a


Correction p481

doi:10.1038/446481b


Top

Business

Biofuels bandwagon hits a rut p483

As politicians propose higher biofuel targets, soaring maize prices in the United States are putting new investment in ethanol production on hold. Lucy Odling-Smee reports.

doi:10.1038/446483a


Top

News Features

Stem cells: The hard copy p485

Researchers have found certain stem-cell studies notoriously difficult to replicate. Erika Check finds out why, and whether it is slowing down the field.

doi:10.1038/446485a

See also: Editor's summary


Science and art: A leap of faith p488

How much can geometry and mathematics reveal about paintings? How far should hidden meanings be trusted in art? Jo Marchant investigates the latest, and possibly most controversial, interpretation of a Renaissance masterpiece.

doi:10.1038/446488a

See also: Editor's summary


Top

Correspondence

Research loses in hasty changes to medical training p492

Ben Seymour

doi:10.1038/446492a


Confidentiality is essential in misconduct inquiries p492

Sally Mason & Charles Rutledge

doi:10.1038/446492b


New species show how little we know of the sea p492

Shane Guan

doi:10.1038/446492c


Top

Books and Arts

All systems go p493

Three authors present very different views of the developing field of systems biology.

Eric Werner reviews Life: An Introduction to Complex Systems Biology by Kunihiko Kaneko and An Introduction to Systems Biology: Design Principles of Biological Circuits by Uri Alon and Systems Biology: Properties of Reconstructed Networks by Bernhard Palsson

doi:10.1038/446493a

See also: Editor's summary


A little movement p494

Tom McLeish reviews Middle World: The Restless Heart of Matter and Life by Mark Haw

doi:10.1038/446494a


A Turkish revolution p495

Martin Harwit reviews Turkey's Modernization: Refugees from Nazism and Atatürk's Vision by Arnold Reisman

doi:10.1038/446495a


Science in culture: Gene expression p496

Sarah Jacobs mutates genetic information into art.

Martin Kemp

doi:10.1038/446496a


Top

Essay

Connections

Simplicity in biology p497

Networks of interactions between thousands of molecules within cells seem to defy comprehension, but shared principles of design may simplify the picture.

Uri Alon

doi:10.1038/446497a

See also: Editor's summary


Top

News and Views

Chemical biology: A degrading solution to pollution p499

Environmental pollutants such as dioxins affect human health. It now seems that dioxins exert their effect by forming atypical enzyme complexes that mediate the breakdown of steroid-hormone receptors.

J. Wade Harper

doi:10.1038/446499a

See also: Editor's summary


Microscopy: Tip-top imaging p500

Images of nanoscale structures can be constructed using the flow of electrons ejected from a metal probe tip by a fast laser pulse. The technique adds new dimensions to established methods of microscopy.

Herman Batelaan & Kees Uiterwaal

doi:10.1038/446500a


Evolutionary biology: Mass survivals p501

The conclusion that the primary divergences of the modern groups of mammals occurred in the mid-Cretaceous requires fresh thinking about this facet of evolutionary history — especially in ecological terms.

David Penny & Matthew J. Phillips

doi:10.1038/446501a

See also: Editor's summary


Behavioural genetics: Sex, flies and acetate p502

A receptor molecule in the fruitfly Drosophila melanogaster responds to a male pheromone in both sexes. But the effect of this response on sexual behaviour is not the same in males and females.

Charalambos P. Kyriacou

doi:10.1038/446502a

See also: Editor's summary


50 & 100 Years Ago p504

doi:10.1038/446504a


Solid-state physics: Vacillating valence p504

Electrons in one particular solid phase of plutonium are complex characters: while bound to atoms, in a quantum-mechanical mixture of two different valence states, they also roam freely throughout the crystal.

Robert C. Albers & Jian-Xin Zhu

doi:10.1038/446504b

See also: Editor's summary


Chemistry: Compliments from Lord Kelvin p505

Telling if a molecule is right-handed or left-handed is a venerable problem, but traditional approaches cannot touch the subtlest cases. As so often, technical innovation has provided the way forward.

Laurence D. Barron

doi:10.1038/446505a

See also: Editor's summary


Correction p506

doi:10.1038/446506a


Top

Brief Communications Arising

Ecology: Diversity and stability in plant communities pE6

T. Martijn Bezemer & Wim H. van der Putten

doi:10.1038/nature05749


Ecology: Diversity and stability in plant communities (Reply) pE7

David Tilman, Peter B. Reich & Johannes Knops

doi:10.1038/nature05750


Top

Article

The delayed rise of present-day mammals p507

Olaf R. P. Bininda-Emonds, Marcel Cardillo, Kate E. Jones, Ross D. E. MacPhee, Robin M. D. Beck, Richard Grenyer, Samantha A. Price, Rutger A. Vos, John L. Gittleman & Andy Purvis

doi:10.1038/nature05634

See also: Editor's summary | News and Views by Penny & Phillips


Top

Letters

Fluctuating valence in a correlated solid and the anomalous properties of delta-plutonium p513

J. H. Shim, K. Haule & G. Kotliar

doi:10.1038/nature05647

See also: Editor's summary | News and Views by Albers & Zhu


Transmission resonances through aperiodic arrays of subwavelength apertures p517

Tatsunosuke Matsui, Amit Agrawal, Ajay Nahata & Z. Valy Vardeny

doi:10.1038/nature05620

See also: Editor's summary


Magnetic exchange force microscopy with atomic resolution p522

Uwe Kaiser, Alexander Schwarz & Roland Wiesendanger

doi:10.1038/nature05617

See also: Editor's summary


Absolute configuration of chirally deuterated neopentane p526

J. Haesler, I. Schindelholz, E. Riguet, C. G. Bochet & W. Hug

doi:10.1038/nature05653

See also: Editor's summary | News and Views by Barron


Climate sensitivity constrained by CO2 concentrations over the past 420 million years p530

Dana L. Royer, Robert A. Berner & Jeffrey Park

doi:10.1038/nature05699

See also: Editor's summary


Seasonal dynamics of recurrent epidemics p533

Lewi Stone, Ronen Olinky & Amit Huppert

doi:10.1038/nature05638

See also: Editor's summary


Strain-resolved community proteomics reveals recombining genomes of acidophilic bacteria p537

Ian Lo, Vincent J. Denef, Nathan C. VerBerkmoes, Manesh B. Shah, Daniela Goltsman, Genevieve DiBartolo, Gene W. Tyson, Eric E. Allen, Rachna J. Ram, J. Chris Detter, Paul Richardson, Michael P. Thelen, Robert L. Hettich & Jillian F. Banfield

doi:10.1038/nature05624

See also: Editor's summary


A single class of olfactory neurons mediates behavioural responses to a Drosophila sex pheromone p542

Amina Kurtovic, Alexandre Widmer & Barry J. Dickson

doi:10.1038/nature05672

See also: Editor's summary | News and Views by Kyriacou


Tyrosine kinase receptor RET is a key regulator of Peyer's Patch organogenesis p547

Henrique Veiga-Fernandes, Mark C. Coles, Katie E. Foster, Amisha Patel, Adam Williams, Dipa Natarajan, Amanda Barlow, Vassilis Pachnis & Dimitris Kioussis

doi:10.1038/nature05597


Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis p552

Colby Zaph, Amy E. Troy, Betsy C. Taylor, Lisa D. Berman-Booty, Katherine J. Guild, Yurong Du, Evan A. Yost, Achim D. Gruber, Michael J. May, Florian R. Greten, Lars Eckmann, Michael Karin & David Artis

doi:10.1038/nature05590


Epithelial NEMO links innate immunity to chronic intestinal inflammation p557

Arianna Nenci, Christoph Becker, Andy Wullaert, Ralph Gareus, Geert van Loo, Silvio Danese, Marion Huth, Alexei Nikolaev, Clemens Neufert, Blair Madison, Deborah Gumucio, Markus F. Neurath & Manolis Pasparakis

doi:10.1038/nature05698


Dioxin receptor is a ligand-dependent E3 ubiquitin ligase p562

Fumiaki Ohtake, Atsushi Baba, Ichiro Takada, Maiko Okada, Kei Iwasaki, Hiromi Miki, Sayuri Takahashi, Alexander Kouzmenko, Keiko Nohara, Tomoki Chiba, Yoshiaki Fujii-Kuriyama & Shigeaki Kato

doi:10.1038/nature05683

See also: Editor's summary | News and Views by Harper


Structure of the yeast polarity protein Sro7 reveals a SNARE regulatory mechanism p567

Douglas A. Hattendorf, Anna Andreeva, Akanksha Gangar, Patrick J. Brennwald & William I. Weis

doi:10.1038/nature05635


Translational and rotational settings of H2A.Z nucleosomes across the Saccharomycescerevisiae genome p572

Istvan Albert, Travis N. Mavrich, Lynn P. Tomsho, Ji Qi, Sara J. Zanton, Stephan C. Schuster & B. Franklin Pugh

doi:10.1038/nature05632


Top

Naturejobs

Prospect

Prospects p577

Being a pioneer has its own set of rewards and challenges.

Paul Smaglik

doi:10.1038/nj7135-577a


Region

Alternatives in Colorado p578

Despite tight government budgets, Colorado is brimming with alternative-energy jobs potential. Amanda Haag reports.

Amanda Haag

doi:10.1038/nj7135-578a


Career Views

Sally Benson, executive director, Global Climate and Energy Project, Stanford University, California p580

Stanford's climate and energy project gets new director

Virginia Gewin

doi:10.1038/nj7135-580a


Opportunities in Poland p580

Polish researchers who head home have more opportunities than they used to

Jacek Kuznicki & Marta Miaczynska

doi:10.1038/nj7135-580b


Recruiters

The inside track from academia and industry: Translating science into business p582

The right kind of postgraduate training could help you to realize biotech's potential as well as your own.

Sheldon Schuster

doi:10.1038/nj7135-582a


Spotlight

Spotlight on Colorado

doi:10.1038/nj0151


Extra navigation

.
  • Japanese table of contents
ADVERTISEMENT