FIGURE 1. Intestinal epithelium-specific NEMO ablation causes severe spontaneous colitis.
From the following article:
Epithelial NEMO links innate immunity to chronic intestinal inflammation
Arianna Nenci, Christoph Becker, Andy Wullaert, Ralph Gareus, Geert van Loo, Silvio Danese, Marion Huth, Alexei Nikolaev, Clemens Neufert, Blair Madison, Deborah Gumucio, Markus F. Neurath & Manolis Pasparakis
Nature 446, 557-561(29 March 2007)
doi:10.1038/nature05698
a, Immunofluorescence with anti-NEMO antibodies shows efficient NEMO ablation in the intestinal epithelium of NEMOIEC-KO mice. WT, wild type. b, Southern blot DNA analysis shows NEMO deletion (Del) specifically in the intestines of NEMOIEC-KO mice. c, NEMOIEC-KO (n = 3) and wild-type (n = 5) mice were examined at the age of 32–36 weeks using mini-endoscopy. Murine endoscopic index of colitis severity (MEICS)29 scores are shown (mean
s.d.). d, The colon of NEMOIEC-KO mice is thickened and shortened, indicating severe colitis. e, Haematoxylin-and-eosin-stained colon cross-sections show severe inflammation and loss of goblet cells in NEMOIEC-KO mice. All scale bars, 50 
m.
