Table of contents
Volume 446 Number 7135 pp469-582
(this content only available online) indicates content that is available online only
Editorials
Safe in their hands? p469
Britain's restructuring of research funding and the budget announced last week are welcome. But a cloud still hangs over basic biomedical science.
doi:10.1038/446469a
Mutant mice galore p469
A new consortium will fulfil a genomics dream — provided it gets the support it deserves.
doi:10.1038/446469b
Cut the climate antics p470
A long run of congressional theatre should close.
doi:10.1038/446470a
News
Cancer patients opt for unapproved drug p474
Internet trade pre-empts clinical trial.
Helen Pearson
doi:10.1038/446474a
Database targets Parsi genes p475
Biotech firm aims to collate health data for 69,000-strong community.
K. S. Jayaraman
doi:10.1038/446475a
Sidelines p476
doi:10.1038/446476a
Chinese network to start trials of spinal surgery p476
Surgeons agree on guidelines for stem-cell operations.
David Cyranoski
doi:10.1038/446476b
Snapshot p477
Hinode spacecraft changes our view of the Sun.
doi:10.1038/446477a
Darwin and the 20-year publication gap p478
Was On the Origin of Species really delayed by religious fears?
Lucy Odling-Smee
doi:10.1038/446478a
Q&A: A vision for Italy's role in space p478
Giovanni Bignami, incoming president of the Italian Space Agency, looks to the future.
doi:10.1038/446478b
Congress requests bubble-fusion reports p480
Spotlight falls on Purdue's inquiry.
Eugenie Samuel Reich
doi:10.1038/446480a
News in brief p481
doi:10.1038/446481a
Correction p481
doi:10.1038/446481b
Business
Biofuels bandwagon hits a rut p483
As politicians propose higher biofuel targets, soaring maize prices in the United States are putting new investment in ethanol production on hold. Lucy Odling-Smee reports.
doi:10.1038/446483a
News Features
Stem cells: The hard copy p485
Researchers have found certain stem-cell studies notoriously difficult to replicate. Erika Check finds out why, and whether it is slowing down the field.
doi:10.1038/446485a
See also: Editor's summary
Science and art: A leap of faith p488
How much can geometry and mathematics reveal about paintings? How far should hidden meanings be trusted in art? Jo Marchant investigates the latest, and possibly most controversial, interpretation of a Renaissance masterpiece.
doi:10.1038/446488a
See also: Editor's summary
Correspondence
Research loses in hasty changes to medical training p492
Ben Seymour
doi:10.1038/446492a
Confidentiality is essential in misconduct inquiries p492
Sally Mason & Charles Rutledge
doi:10.1038/446492b
New species show how little we know of the sea p492
Shane Guan
doi:10.1038/446492c
Books and Arts
All systems go p493
Three authors present very different views of the developing field of systems biology.
Eric Werner reviews Life: An Introduction to Complex Systems Biology by Kunihiko Kaneko and An Introduction to Systems Biology: Design Principles of Biological Circuits by Uri Alon and Systems Biology: Properties of Reconstructed Networks by Bernhard Palsson
doi:10.1038/446493a
See also: Editor's summary
A little movement p494
Tom McLeish reviews Middle World: The Restless Heart of Matter and Life by Mark Haw
doi:10.1038/446494a
A Turkish revolution p495
Martin Harwit reviews Turkey's Modernization: Refugees from Nazism and Atatürk's Vision by Arnold Reisman
doi:10.1038/446495a
Science in culture: Gene expression p496
Sarah Jacobs mutates genetic information into art.
Martin Kemp
doi:10.1038/446496a
Essay
ConnectionsSimplicity in biology p497
Networks of interactions between thousands of molecules within cells seem to defy comprehension, but shared principles of design may simplify the picture.
Uri Alon
doi:10.1038/446497a
See also: Editor's summary
News and Views
Chemical biology: A degrading solution to pollution p499
Environmental pollutants such as dioxins affect human health. It now seems that dioxins exert their effect by forming atypical enzyme complexes that mediate the breakdown of steroid-hormone receptors.
J. Wade Harper
doi:10.1038/446499a
See also: Editor's summary
Microscopy: Tip-top imaging p500
Images of nanoscale structures can be constructed using the flow of electrons ejected from a metal probe tip by a fast laser pulse. The technique adds new dimensions to established methods of microscopy.
Herman Batelaan & Kees Uiterwaal
doi:10.1038/446500a
Evolutionary biology: Mass survivals p501
The conclusion that the primary divergences of the modern groups of mammals occurred in the mid-Cretaceous requires fresh thinking about this facet of evolutionary history — especially in ecological terms.
David Penny & Matthew J. Phillips
doi:10.1038/446501a
See also: Editor's summary
Behavioural genetics: Sex, flies and acetate p502
A receptor molecule in the fruitfly Drosophila melanogaster responds to a male pheromone in both sexes. But the effect of this response on sexual behaviour is not the same in males and females.
Charalambos P. Kyriacou
doi:10.1038/446502a
See also: Editor's summary
50 & 100 Years Ago p504
doi:10.1038/446504a
Solid-state physics: Vacillating valence p504
Electrons in one particular solid phase of plutonium are complex characters: while bound to atoms, in a quantum-mechanical mixture of two different valence states, they also roam freely throughout the crystal.
Robert C. Albers & Jian-Xin Zhu
doi:10.1038/446504b
See also: Editor's summary
Chemistry: Compliments from Lord Kelvin p505
Telling if a molecule is right-handed or left-handed is a venerable problem, but traditional approaches cannot touch the subtlest cases. As so often, technical innovation has provided the way forward.
Laurence D. Barron
doi:10.1038/446505a
See also: Editor's summary
Correction p506
doi:10.1038/446506a
Brief Communications Arising
Ecology: Diversity and stability in plant communities pE6
T. Martijn Bezemer & Wim H. van der Putten
doi:10.1038/nature05749
First paragraph | Full Text | PDF (149K)
Ecology: Diversity and stability in plant communities (Reply) pE7
David Tilman, Peter B. Reich & Johannes Knops
doi:10.1038/nature05750
First paragraph | Full Text | PDF (149K)
Article
The delayed rise of present-day mammals p507
Olaf R. P. Bininda-Emonds, Marcel Cardillo, Kate E. Jones, Ross D. E. MacPhee, Robin M. D. Beck, Richard Grenyer, Samantha A. Price, Rutger A. Vos, John L. Gittleman & Andy Purvis
doi:10.1038/nature05634
Abstract | Full Text | PDF (685K) | Supplementary information
See also: Editor's summary | News and Views by Penny & Phillips
Letters
Fluctuating valence in a correlated solid and the anomalous properties of 
-plutonium p513
J. H. Shim, K. Haule & G. Kotliar
doi:10.1038/nature05647
First paragraph | Full Text | PDF (269K) | Supplementary information
See also: Editor's summary | News and Views by Albers & Zhu
Transmission resonances through aperiodic arrays of subwavelength apertures p517
Tatsunosuke Matsui, Amit Agrawal, Ajay Nahata & Z. Valy Vardeny
doi:10.1038/nature05620
First paragraph | Full Text | PDF (439K) | Supplementary information
See also: Editor's summary
Magnetic exchange force microscopy with atomic resolution p522
Uwe Kaiser, Alexander Schwarz & Roland Wiesendanger
doi:10.1038/nature05617
First paragraph | Full Text | PDF (933K) | Supplementary information
See also: Editor's summary
Absolute configuration of chirally deuterated neopentane p526
J. Haesler, I. Schindelholz, E. Riguet, C. G. Bochet & W. Hug
doi:10.1038/nature05653
First paragraph | Full Text | PDF (337K) | Supplementary information
See also: Editor's summary | News and Views by Barron
Climate sensitivity constrained by CO2 concentrations over the past 420 million years p530
Dana L. Royer, Robert A. Berner & Jeffrey Park
doi:10.1038/nature05699
First paragraph | Full Text | PDF (246K) | Supplementary information
See also: Editor's summary
Seasonal dynamics of recurrent epidemics p533
Lewi Stone, Ronen Olinky & Amit Huppert
doi:10.1038/nature05638
First paragraph | Full Text | PDF (409K) | Supplementary information
See also: Editor's summary
Strain-resolved community proteomics reveals recombining genomes of acidophilic bacteria p537
Ian Lo, Vincent J. Denef, Nathan C. VerBerkmoes, Manesh B. Shah, Daniela Goltsman, Genevieve DiBartolo, Gene W. Tyson, Eric E. Allen, Rachna J. Ram, J. Chris Detter, Paul Richardson, Michael P. Thelen, Robert L. Hettich & Jillian F. Banfield
doi:10.1038/nature05624
First paragraph | Full Text | PDF (2,348K) | Supplementary information
See also: Editor's summary
A single class of olfactory neurons mediates behavioural responses to a Drosophila sex pheromone p542
Amina Kurtovic, Alexandre Widmer & Barry J. Dickson
doi:10.1038/nature05672
First paragraph | Full Text | PDF (414K) | Supplementary information
See also: Editor's summary | News and Views by Kyriacou
Tyrosine kinase receptor RET is a key regulator of Peyer's Patch organogenesis p547
Henrique Veiga-Fernandes, Mark C. Coles, Katie E. Foster, Amisha Patel, Adam Williams, Dipa Natarajan, Amanda Barlow, Vassilis Pachnis & Dimitris Kioussis
doi:10.1038/nature05597
First paragraph | Full Text | PDF (488K) | Supplementary information
Epithelial-cell-intrinsic IKK-
expression regulates intestinal immune homeostasis p552
Colby Zaph, Amy E. Troy, Betsy C. Taylor, Lisa D. Berman-Booty, Katherine J. Guild, Yurong Du, Evan A. Yost, Achim D. Gruber, Michael J. May, Florian R. Greten, Lars Eckmann, Michael Karin & David Artis
doi:10.1038/nature05590
First paragraph | Full Text | PDF (570K) | Supplementary information
Epithelial NEMO links innate immunity to chronic intestinal inflammation p557
Arianna Nenci, Christoph Becker, Andy Wullaert, Ralph Gareus, Geert van Loo, Silvio Danese, Marion Huth, Alexei Nikolaev, Clemens Neufert, Blair Madison, Deborah Gumucio, Markus F. Neurath & Manolis Pasparakis
doi:10.1038/nature05698
First paragraph | Full Text | PDF (1,722K) | Supplementary information
Dioxin receptor is a ligand-dependent E3 ubiquitin ligase p562
Fumiaki Ohtake, Atsushi Baba, Ichiro Takada, Maiko Okada, Kei Iwasaki, Hiromi Miki, Sayuri Takahashi, Alexander Kouzmenko, Keiko Nohara, Tomoki Chiba, Yoshiaki Fujii-Kuriyama & Shigeaki Kato
doi:10.1038/nature05683
First paragraph | Full Text | PDF (1,220K) | Supplementary information
See also: Editor's summary | News and Views by Harper
Structure of the yeast polarity protein Sro7 reveals a SNARE regulatory mechanism p567
Douglas A. Hattendorf, Anna Andreeva, Akanksha Gangar, Patrick J. Brennwald & William I. Weis
doi:10.1038/nature05635
First paragraph | Full Text | PDF (922K) | Supplementary information
Translational and rotational settings of H2A.Z nucleosomes across the Saccharomycescerevisiae genome p572
Istvan Albert, Travis N. Mavrich, Lynn P. Tomsho, Ji Qi, Sara J. Zanton, Stephan C. Schuster & B. Franklin Pugh
doi:10.1038/nature05632
First paragraph | Full Text | PDF (988K) | Supplementary information
Naturejobs
ProspectProspects p577
Being a pioneer has its own set of rewards and challenges.
Paul Smaglik
doi:10.1038/nj7135-577a
Region
Alternatives in Colorado p578
Despite tight government budgets, Colorado is brimming with alternative-energy jobs potential. Amanda Haag reports.
Amanda Haag
doi:10.1038/nj7135-578a
Career Views
Sally Benson, executive director, Global Climate and Energy Project, Stanford University, California p580
Stanford's climate and energy project gets new director
Virginia Gewin
doi:10.1038/nj7135-580a
Opportunities in Poland p580
Polish researchers who head home have more opportunities than they used to
Jacek Kuznicki & Marta Miaczynska
doi:10.1038/nj7135-580b
Recruiters
The inside track from academia and industry: Translating science into business p582
The right kind of postgraduate training could help you to realize biotech's potential as well as your own.
Sheldon Schuster
doi:10.1038/nj7135-582a
Spotlight
Spotlight on Colorado
doi:10.1038/nj0151