Fragile chemical groups can be shielded from harsh reaction conditions by temporary protection. This approach is conventional wisdom for organic synthesis, but is it always the best solution?
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References
Baran, P. S., Maimone, T. J. & Richter, J. M. Nature 446, 404–408 (2007).
Greene, T. W. & Wuts, P. G. M. Protective Groups in Organic Synthesis (Wiley-Interscience, New York, 2006).
Kocienski, P. J. Protecting Groups (Thieme, Stuttgart, 2003).
Hoffmann, R. W. Synthesis 3531–3541 (2006).
Lichtenthaler, F. W. Angew. Chem. Int. Edn 31, 1541–1556 (1992).
Hardegger, E. & Lohse, F. Helv. Chim. Acta 40, 2383–2389 (1957).
Robinson, R. J. Chem. Soc. Trans. 111, 762–768 (1917).
Nicolaou, K. C., Montagnon, T. & Snyder, S. A. Chem. Commun. 551–564 (2003).
Whitesides, G. M. & Wong, C.-H. Aldrichim. Acta 16, 27–34 (1983).
Koeller, K. M. & Wong, C.-H. Nature 409, 232–240 (2001).
Baran, P. S. & Richter, J. M. J. Am. Chem. Soc. 126, 7450–7451 (2004).
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Porco, J. Synthesis undressed. Nature 446, 383–385 (2007). https://doi.org/10.1038/446383a
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DOI: https://doi.org/10.1038/446383a