Patterns of somatic mutation in human cancer genomes

doi:doi:10.1038/nature05610

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Patterns of somatic mutation in human cancer genomes

Christopher Greenman, Philip Stephens, Raffaella Smith, Gillian L. Dalgliesh, Christopher Hunter, Graham Bignell, Helen Davies, Jon Teague, Adam Butler, Claire Stevens, Sarah Edkins, Sarah O'Meara, Imre Vastrik, Esther E. Schmidt, Tim Avis, Syd Barthorpe, Gurpreet Bhamra, Gemma Buck, Bhudipa Choudhury, Jody Clements, Jennifer Cole, Ed Dicks, Simon Forbes, Kris Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jon Hinton, Andy Jenkinson, David Jones, Andy Menzies, Tatiana Mironenko, Janet Perry, Keiran Raine, Dave Richardson, Rebecca Shepherd, Alexandra Small, Calli Tofts, Jennifer Varian, Tony Webb, Sofie West, Sara Widaa, Andy Yates, Daniel P. Cahill, David N. Louis, Peter Goldstraw, Andrew G. Nicholson, Francis Brasseur, Leendert Looijenga, Barbara L. Weber, Yoke-Eng Chiew, Anna deFazio, Mel F. Greaves, Anthony R. Green, Peter Campbell, Ewan Birney, Douglas F. Easton, Georgia Chenevix-Trench, Min-Han Tan, Sok Kean Khoo, Bin Tean Teh, Siu Tsan Yuen, Suet Yi Leung, Richard Wooster, P. Andrew Futreal and Michael R. Stratton

Nature 446, 153-158(8 March 2007)

doi:10.1038/nature05610

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Supplementary Information

This file contains Supplementary Methods and Supplementary Tables 1-5 with Legends and Supplementary Figure 1. The Supplementary Tables show protein kinase genes in the screen (Table 1); somatic mutations indentified (Table 2); cancer samples analysed (Table 3); germline variants identified (Table 4) and kinase gene ranking by probability of carrying driver mutations (Table 5). The Supplementary Figure 1 illustrates mutation prevalence in individual cancers across cancer types

Supplementary Information - Download PDF file (2.5MB)

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