Table of contents
Volume 446 Number 7132 pp109-230
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Editorials
No more hot air p109
European heads of state gathered in Brussels today must show they are serious about climate change.
doi:10.1038/446109a
Tackling tuberculosis p109
There is a dangerous gulf between the global programmes to fight AIDS and TB.
doi:10.1038/446109b
The ends of the Earth p110
International Polar Year 2007 can leave an imprint.
doi:10.1038/446110a
See also: Editor's summary
News
Western states launch carbon scheme p114
Governors team up for cap-and-trade programme.
Emma Marris
doi:10.1038/446114a
Scriptural violence can foster aggression p114
Elements of religious texts seem to inspire bad behaviour.
Heidi Ledford
doi:10.1038/446114b
Our Solar System last week p116
Celestial bodies caught on camera
Katharine Sanderson and Geoff Brumfiel
doi:10.1038/446116a
Biobank provides leads for selecting guide dogs p119
Genetics highlights the pick of the pups.
Ichiko Fuyuno
doi:10.1038/446119a
Sidelines p119
doi:10.1038/446119b
Superconductivity two decades on p120
What happened after the physics Woodstock?
Geoff Brumfiel
doi:10.1038/446120a
Design chosen for nuclear warheads p121
Lawrence Livermore's proposal wins support.
Lucy Odling-Smee
doi:10.1038/446121a
Business
A place in the sun p124
In the Tuscan countryside just outside Siena, a historic laboratory is helping Novartis in its bid to become the world's premier vaccine company. Alison Abbott reports.
doi:10.1038/446124a
In brief p125
doi:10.1038/446125a
Market watch p125
Colin Macilwain
doi:10.1038/446125b
News Features
Polar Research: Buried treasure p126 Free access
Air bubbles trapped in the Antarctic ice sheet could yield precious information about Earth's climate more than a million years ago. But to access this record, scientists first have to climb one of the coldest peaks on Earth. Nicola Jones reports.
doi:10.1038/446126a
See also: Editor's summary
Polar Research: Polar year projects p127
doi:10.1038/446127a
Polar research: School of rock p129
The rocks of Antarctica are obscured literally, and sometimes scientifically, by its ice. But drilling efforts are now showing what we can learn from the hard stuff. Alexandra Witze reports.
doi:10.1038/446129a
See also: Editor's summary
Polar research: The new face of the Arctic p133
Every summer the Arctic Ocean loses more ice — and it could all be gone within decades. Quirin Schiermeier looks at how the vanishing summer ice affects those living in the north.
doi:10.1038/446133a
See also: Editor's summary
Correspondence
Abderhalden's fraud still wins him some supporters p136
U. Kutschera
doi:10.1038/446136a
A Moon base offers more than just a good view p136
Dan Barry
doi:10.1038/446136b
Fossils: new journal will oppose illegal trade p136
Michael Triebold
doi:10.1038/446136c
Commentary
Keeping faith with trial volunteers p137
How best to serve patients' interests in large clinical trials? Martine Piccart, Aron Goldhirsch and their colleagues argue that maintaining academic independence is essential to early breast cancer trials.
doi:10.1038/446137a
See also: Editor's summary
Books and Arts
Immortality of a kind p139
The ability to grow human cells in the laboratory created paradoxes of personal identity.
Nick Hopwood reviews Culturing Life: How Cells Became Technologies by Hannah Landecker
doi:10.1038/446139a
A scientific symphony p140
Peter Pesic reviews Harmonious Triads: Physicists, Musicians, and Instrument Makers in Nineteenth-Century Germany by Myles W. Jackson
doi:10.1038/446140a
See also: Editor's summary
Life at the poles p141
doi:10.1038/446141a
The changing view of autism p141
Lorna Wing reviews Unstrange Minds: Remapping the World of Autism by Roy Richard Grinker
doi:10.1038/446141b
Essay
ConnectionsControl without hierarchy p143
Understanding how particular natural systems operate without central control will reveal whether such systems share general properties.
Deborah M. Gordon
doi:10.1038/446143a
See also: Editor's summary
News and Views
Cancer: Drivers and passengers p145
Studies that have provided the first unbiased, large-scale analyses of DNA mutations across an array of cancers also have lessons for the proposal to annotate the entire cancer genome.
Daniel A. Haber and Jeff Settleman
doi:10.1038/446145a
See also: Editor's summary
Materials science: Silicon life forms p146
A simple chemical reduction process has been used to replicate intricate natural networks of silica at a relatively low temperature. The equally elaborate product is made of silicon — electronics' golden boy.
David J. Norris
doi:10.1038/446146a
See also: Editor's summary
Evolutionary biology: The Elvis paradox p147
Evidence for a universal driver of evolution across all timescales could mean that the venerable paradox of stasis is dead. But even with such evidence, some biologists would be reluctant to accept its passing.
Andrew Hendry
doi:10.1038/446147a
50 & 100 Years Ago p150
doi:10.1038/446150a
Planetary science: Water cycling on Mars p150
The Meridiani Planum region on Mars is rich in minerals derived from evaporation, but lacks a topography consistent with standing water. Do the deposits stem from upwelling groundwater early in the planet's history?
Victor R. Baker
doi:10.1038/446150b
See also: Editor's summary
Plant biology: The force from without p151
It seems that the epidermis is the cell layer through which growth-promoting plant hormones called brassinosteroids exert their effect on cell expansion — a finding that puts a new perspective on classical views of plant growth.
Ben Scheres
doi:10.1038/446151a
See also: Editor's summary
Correction p152
doi:10.1038/446152a
Brief Communication Arising
Scanning-tunnelling spectra of cuprates pE3
Jungseek Hwang, Thomas Timusk and Jules P. Carbotte
doi:10.1038/nature05709
First paragraph | Full Text | PDF (125K)
Article
Patterns of somatic mutation in human cancer genomes p153
Christopher Greenman, Philip Stephens, Raffaella Smith, Gillian L. Dalgliesh, Christopher Hunter, Graham Bignell, Helen Davies, Jon Teague, Adam Butler, Claire Stevens, Sarah Edkins, Sarah O'Meara, Imre Vastrik, Esther E. Schmidt, Tim Avis, Syd Barthorpe, Gurpreet Bhamra, Gemma Buck, Bhudipa Choudhury, Jody Clements, Jennifer Cole, Ed Dicks, Simon Forbes, Kris Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jon Hinton, Andy Jenkinson, David Jones, Andy Menzies, Tatiana Mironenko, Janet Perry, Keiran Raine, Dave Richardson, Rebecca Shepherd, Alexandra Small, Calli Tofts, Jennifer Varian, Tony Webb, Sofie West, Sara Widaa, Andy Yates, Daniel P. Cahill, David N. Louis, Peter Goldstraw, Andrew G. Nicholson, Francis Brasseur, Leendert Looijenga, Barbara L. Weber, Yoke-Eng Chiew, Anna deFazio, Mel F. Greaves, Anthony R. Green, Peter Campbell, Ewan Birney, Douglas F. Easton, Georgia Chenevix-Trench, Min-Han Tan, Sok Kean Khoo, Bin Tean Teh, Siu Tsan Yuen, Suet Yi Leung, Richard Wooster, P. Andrew Futreal and Michael R. Stratton
doi:10.1038/nature05610
Abstract | Full Text | PDF (281K) | Supplementary information
See also: Editor's summary | News and Views by Haber & Settleman
Letters
An ancient nova shell around the dwarf nova Z Camelopardalis p159
Michael M. Shara, Christopher D. Martin, Mark Seibert, R. Michael Rich, Samir Salim, David Reitzel, David Schiminovich, Constantine P. Deliyannis, Angela R. Sarrazine, Shri R. Kulkarni, Eran O. Ofek, Noah Brosch, Sebastien Lépine, David Zurek, Orsola De Marco and George Jacoby
doi:10.1038/nature05576
First paragraph | Full Text | PDF (2,373K)
See also: Editor's summary
Meridiani Planum and the global hydrology of Mars p163
Jeffrey C. Andrews-Hanna, Roger J. Phillips and Maria T. Zuber
doi:10.1038/nature05594
First paragraph | Full Text | PDF (663K) | Supplementary information
See also: Editor's summary | News and Views by Baker
Observation of the two-channel Kondo effect p167
R. M. Potok, I. G. Rau, Hadas Shtrikman, Yuval Oreg and D. Goldhaber-Gordon
doi:10.1038/nature05556
First paragraph | Full Text | PDF (635K) | Supplementary information
See also: Editor's summary
Chemical reduction of three-dimensional silica micro-assemblies into microporous silicon replicas p172
Zhihao Bao, Michael R. Weatherspoon, Samuel Shian, Ye Cai, Phillip D. Graham, Shawn M. Allan, Gul Ahmad, Matthew B. Dickerson, Benjamin C. Church, Zhitao Kang, Harry W. Abernathy III, Christopher J. Summers, Meilin Liu and Kenneth H. Sandhage
doi:10.1038/nature05570
First paragraph | Full Text | PDF (561K) | Supplementary information
See also: Editor's summary | News and Views by Norris
Continental ice in Greenland during the Eocene and Oligocene p176
James S. Eldrett, Ian C. Harding, Paul A. Wilson, Emily Butler and Andrew P. Roberts
doi:10.1038/nature05591
First paragraph | Full Text | PDF (804K) | Supplementary information
See also: Editor's summary
Origin of avian genome size and structure in non-avian dinosaurs p180
Chris L. Organ, Andrew M. Shedlock, Andrew Meade, Mark Pagel and Scott V. Edwards
doi:10.1038/nature05621
First paragraph | Full Text | PDF (380K) | Supplementary information
See also: Editor's summary
A single type of progenitor cell maintains normal epidermis p185
Elizabeth Clayton, David P. Doupé, Allon M. Klein, Douglas J. Winton, Benjamin D. Simons and Philip H. Jones
doi:10.1038/nature05574
First paragraph | Full Text | PDF (795K) | Supplementary information
See also: Editor's summary
Hippocampal remapping and grid realignment in entorhinal cortex p190
Marianne Fyhn, Torkel Hafting, Alessandro Treves, May-Britt Moser and Edvard I. Moser
doi:10.1038/nature05601
First paragraph | Full Text | PDF (1,331K) | Supplementary information
See also: Editor's summary
A cytosolic trans-activation domain essential for ammonium uptake p195
D. Loqué, S. Lalonde, L. L. Looger, N. von Wirén and W. B. Frommer
doi:10.1038/nature05579
First paragraph | Full Text | PDF (629K) | Supplementary information
The epidermis both drives and restricts plant shoot growth p199
Sigal Savaldi-Goldstein, Charles Peto and Joanne Chory
doi:10.1038/nature05618
First paragraph | Full Text | PDF (1,608K) | Supplementary information
See also: Editor's summary | News and Views by Scheres
C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a p203
Nien-Jung Chen, Christine Mirtsos, Daniel Suh, Yong-Chen Lu, Wen-Jye Lin, Colin McKerlie, Taeweon Lee, Helene Baribault, Hui Tian and Wen-Chen Yeh
doi:10.1038/nature05559
First paragraph | Full Text | PDF (573K) | Supplementary information
Endonuclease-independent LINE-1 retrotransposition at mammalian telomeres p208
Tammy A. Morrish, José Luis Garcia-Perez, Thomas D. Stamato, Guillermo E. Taccioli, JoAnn Sekiguchi and John V. Moran
doi:10.1038/nature05560
First paragraph | Full Text | PDF (744K) | Supplementary information
Structure of an ABC transporter in complex with its binding protein p213
Kaspar Hollenstein, Dominik C. Frei and Kaspar P. Locher
doi:10.1038/nature05626
First paragraph | Full Text | PDF (577K) | Supplementary information
Technology Features
Tools for drug discovery: Tools of the trade p219
Even though the pace of drug discovery is hotting up, many candidate drugs fail late in development. Caitlin Smith looks at some of the tools used early in drug discovery that could help improve the situation.
Caitlin Smith
doi:10.1038/446219a
See also: Editor's summary
Tools for drug discovery: Ion channels get automated p219
doi:10.1038/446219b
Tools for drug discovery: In silico screening with chemical informatics p221
doi:10.1038/446221a
Tools for drug discovery: Table of suppliers p223
doi:10.1038/446223a
Naturejobs
ProspectHas science become nastier? p225
Paul Smaglik
doi:10.1038/nj7132-225a
Postdocs and Students
Breaking with tradition p226
There's more than one way to do postdoctoral research, and unconventional routes can lead to international collaboration, intellectual or personal freedom and better job prospects. Kendall Powell explores the roads less travelled.
Kendall Powell
doi:10.1038/nj7132-226a
Recruiters
The inside track from academia and industry: Follow the money p230
Borders no longer constrain the flow of capital, ideas and talent to emerging centres of excellence.
Michael Alvarez
doi:10.1038/nj7132-230a
Highlights
Highlight: Executive Level Positions
doi:10.1038/nj0149